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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17,-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2´-[1,3]dioxolan]-17-ol
EC Number:
610-527-3
Cas Number:
50407-76-6
Molecular formula:
C23H32O3
IUPAC Name:
(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-1,2,4,7,8,9,10,11,12,13,14,15,16,17,-tetradecahydrospiro[cyclopenta[a]phenanthrene-3,2´-[1,3]dioxolan]-17-ol

Test organisms

Test organisms (species):
Pimephales promelas

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1.1 mg/L
Nominal / measured:
estimated
Remarks on result:
other: QSAR Toolbox
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.34 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. (CM)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1.9 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. (NNM)

Any other information on results incl. tables

Sublethal observations / clinical signs:
Software Database / Method Endpoint Test duration Species Predicted value
QSAR Toolbox Aquatic OASIS LC50 96 h Pimephales promales

1.1

T.E.S.T. Consensus method LC50 96 h Fathead minnow

4.34

T.E.S.T. Nearest neighbor method LC50 96 h Fathead minnow

1.9

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox, T.E.S.T., the predicted values indicated that ethisterone-ketal is hazardous to the fishes. The result meets the requirement of Aquatic Acute Category 2.