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EC number: 255-138-6 | CAS number: 40910-49-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- March 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well described summary report. Dose, number of animals (with details), experimental design and observation period are described in the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- not present at the time of performance.
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene
- EC Number:
- 255-138-6
- EC Name:
- 3-(1-ethoxyethoxy)-3,7-dimethylocta-1,6-diene
- Cas Number:
- 40910-49-4
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 1-[(3,7-dimethylocta-1,6-dien-3-yl)oxy]-1-ethoxyethane
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Elintaal
- Description: clear, colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar-derived
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: from TNO colony
- Age at study initiation: young adults
- Weight at study initiation: males: 135 - 248 g; females: 153 - 196 g
- Fasting period before study: overnight
- Housing: housed in groups of five animals in screen-bottomed stainless steel cages
- Diet: stock diet ad libitum
- Water: tap water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 -25
- Humidity (%): no data
- Air changes (per hr): well-ventilated
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSE VOLUME APPLIED: 1.25, 2.5, 5.0 and 10.0 mL/kg body weight
- No. of animals per sex per dose:
- 3
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: All animals looked quite healthy throughout the observation period.
- Gross pathology:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity with rats, an LD50 >10 mL/kg bw was determined.
- Executive summary:
Elintaal was tested in an acute oral toxicity study with male and female rats at 1.25, 2.5, 5.0 and 10.0 mL/kg body weight. No deaths occurred. All animals looked quite healthy throughout the observation period. Based on the results, an LD50 >10 mL/kg bodyweight was determined.
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