Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-795-0 | CAS number: 593-51-1
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance Methylamine hydrochloride (CAS no. 593 -51 -1). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 84, 96 and 100% degradation by O2consumption, BOD(NH3), TOC removal, test mat. analysis and HPLC parameter in 14 days.Thus, based on percentage degradation, Methylamine hydrochloride is considered to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound methanaminium chloride (CAS No. 593 -51 -1). If released in to the environment, 29% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of methanaminium chloride in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of methanaminium chloride in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of chemical into the sediment is less than 1% (i.e, reported as 0.0693%), indicating that the chemical methanaminium chloride is not persistent in sediment.
Biodegradation in soil
The half-life period of methanaminium chloride (CAS No. 593 -51 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 71% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of methanaminium chloride in soil is estimated to be 30 days (720 hrs). Based on this half-life value of methanaminium chloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Bioaccumulation: aquatic / sediment:
From BCFBAF Program (v3.00) model of EPI suite the estimated bio concentration factor (BCF) for Methylamine hydrochloride is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that chemical Methylamine hydrochloride is not expected to be bioaccumulative in fish and the food chain.
Additional information
Biodegradation in water
Various study and predicted data for the target compound methanaminium chloride (CAS no. 593 -51 -1) and 3 supporting studies (from authoritative database) for its closest read across substance with logKow as the primary descriptor were reviewed for the biodegradation end point which are summarized as below:
In an experimental key study (J-CHECK, 2016),biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of test substance Methylamine hydrochloride (CAS no. 593 -51 -1). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 84, 96 and 100% degradation by O2consumption, BOD(NH3), TOC removal, test mat. analysis and HPLC parameter in 14 days. Thus, based on percentage degradation, Methylamine hydrochloride is considered to be readily biodegradable in nature.
In a predicted data done using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound methanaminium chloride (CAS no. 593 -51 -1) in the presence of mixed populations of environmental microorganisms was estimated. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI LInear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that methanaminium chloride is expected to be readily biodegradable.
For read across substance Monomethylamine (CAS no. 74 -89 -5), biodegradation study was conducted for evaluating the percentage biodegradability of substance Monomethylamine (HSDB, 2016). The percentage degradation of test substance was determined to be 67.8% degradation by BOD parameter in 13 days. Thus, based on percentage degradation, Monomethylamine is considered to be readily biodegradable in nature.
Another supporting biodegradation study (HSDB, 2016) was carried out for 28 days for evaluating the percentage biodegradability of the read across substance Monomethylamine (CAS no. 74 -89 -5).The study was performed according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test). The percentage degradation of test substance was determined to be107% by ThOD parameter in 28 days. Thus, based on percentage degradation, Monomethylamine is considered to be readily biodegradable in nature.
In an additional study of the same read acrosssubstance Monomethylamine (CAS no. 74 -89 -5) from authoritative database (HSDB, 2016), biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance Monomethylamine. The study was performed according to OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test). The percentage degradation of test substance was determined to be 96% by DOC removal parameter in 28 days. Thus, based on percentage degradation, Monomethylamine is considered to be readily biodegradable in nature.
On the basis of above results for target chemical methanaminium chloride (from authoritative database J-CHECK and EPI Suite) and for its read across substance (from HSDB authoritative database), it can be concluded that the test substance methanaminium chloride can be expected to be readily biodegradable in nature.
Biodegradation in water and sediment
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound methanaminium chloride (CAS No. 593 -51 -1). If released in to the environment, 29% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of methanaminium chloride in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of methanaminium chloride in sediment is estimated to be 135 days (3240 hrs). However, as the percentage release of chemical into the sediment is less than 1% (i.e, reported as 0.0693%), indicating that the chemical methanaminium chloride is not persistent in sediment.
Biodegradation in soil
The half-life period of methanaminium chloride (CAS No. 593 -51 -1) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 71% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of methanaminium chloride in soil is estimated to be 30 days (720 hrs). Based on this half-life value of methanaminium chloride, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
On the basis of available information, the test substancemethanaminium chloridecan be considered to be readilybiodegradable in nature.
Bioaccumulation: aquatic / sediment:
Three different studies including those from validated prediction databases and experimental study for bioaccumulation endpoint of target chemical Methylamine hydrochloride (Cas no. 593-51-1) and relevant read across which is basic structure of the target chemical are summarized as followed:
Prediction done using the BCFBAF (v3.00) model of EPI Suite program indicated the estimated bio concentration factor (BCF) for Methylamine hydrochloride as 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.
Another prediction database PBT profiler proposed the Bioaccumulation factor (BCF) was predicted to be 3.2 L/kg wet-wt at 25 deg.C for test chemical Methylamine hydrochloride.
Further, an experimental study of basic structure chemical Monomethylamine or methylamine (Cas no. 74-89-5) supports the above predicted results of target substance. It suggested an estimated BCF of 3 was calculated in fish for methylamine, using a log Kow of -0.57 and a regression-derived equation. This BCF suggests the potential for bioconcentration in aquatic organisms is low. (HSDB database; 2017)
All values for bioaccumulation is in the range of 3 -3.2 (L/kg or dimensionless) conclude that the target chemical Methylamine hydrochloride (Cas no. 593-51-1) is not expected to be bioaccumulative in fish and the food chain.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
