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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 August 2015 to 28 August 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study performed in accordance with OECD, EU & US EPA test guidelines in compliance with GLP and reported with a valid certificate.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
See Any other information for details
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
yes
Remarks:
see Any other information for details
Qualifier:
according to
Guideline:
EPA OPPTS 830.7840 (Water Solubility)
Deviations:
yes
Remarks:
see Any other information for details
GLP compliance:
yes (incl. certificate)
Type of method:
column elution method
Water solubility:
< 0.025 mg/L
Temp.:
19.9 °C
pH:
6.3 - 8.2
Remarks on result:
other: The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates.
Details on results:
The column elution method was applied for the determination of the water solubility of 2,2-Bis[[3-(dodecylthio)-1-oxopropoxy]methyl]propane-1,3-diyl bis[3-(dodecylthio)propionate].
All analysed concentrations of the water-solubility samples were below the lower limit of quantification (LLOQ, 0.025 mg/l). 2,2-Bis[[3-(dodecylthio)-1-oxopropoxy]methyl]propane-1,3-diyl bis[3-(dodecylthio)propionate] was detected in high quantities when the loaded column material was analysed. This proved that the column was not depleted when the water solubility samples were taken.
Conclusions:
Interpretation of results (migrated information): insoluble (< 0.1 mg/L)
All analysed concentrations of the water-solubility samples were below the lower limit of quantification (LLOQ, 0.025 mg/l).
Executive summary:

The purpose of the study was to determine the water solubility of 2,2-Bis[[3-(dodecylthio)-1-oxopropoxy]methyl]propane-1,3-diyl bis[3-(dodecylthio)propionate].

 

The study was performed to the following guidelines:

European Community (EC), EC no. 260/2014, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.6: “Water Solubility”, Official Journal of the European Union no. L81, March 19, 2014.

Organization for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals no. 105: "Water Solubility", July 27, 1995.

United States Environmental Protection Agency (EPA), Product Properties Test Guidelines no. OPPTS 830.7840: "Water Solubility: Column Elution Method; Shake Flask Method", March 1998.

 

The column elution method was applied for the determination of the water solubility of 2,2-Bis[[3- (dodecylthio)-1-oxopropoxy]methyl]propane-1,3-diyl bis[3-(dodecylthio)propionate].

All analysed concentrations of the water-solubility samples were below the lower limit of quantification (LLOQ, 0.025 mg/l). 2,2-Bis[[3-(dodecylthio)-1-oxopropoxy]methyl]propane-1,3-diyl bis[3-(dodecylthio)propionate] was detected in high quantities when the loaded column material was analysed. This proved that the column was not depleted when the water solubility samples were taken.

Description of key information

Key value determined in laboratory study using the column elution method is accordance with OECD Guideline 105, EU Method A6 and US EPA Procedure 830.7840.

Key value for chemical safety assessment

Water solubility:
0.025 mg/L
at the temperature of:
19.9 °C

Additional information

All analysed concentrations of the water-solubility samples were below the lower limit of quantification (LLOQ, 0.025 mg/l). 2,2-Bis[[3-(dodecylthio)-1-oxopropoxy]methyl]propane-1,3-diyl bis[3-(dodecylthio)propionate] was detected in high quantities when the loaded column material was analysed. This proved that the column was not depleted when the water solubility samples were taken.