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EC number: 297-566-6 | CAS number: 93642-68-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- 1987
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-[3-(triethoxysilyl)propyl]oxolane-2,5-dione
- IUPAC Name:
- 3-[3-(triethoxysilyl)propyl]oxolane-2,5-dione
- Reference substance name:
- Dihydro-3-[3-(triethoxysilyl)propyl]furan-2,5-dione
- EC Number:
- 297-566-6
- EC Name:
- Dihydro-3-[3-(triethoxysilyl)propyl]furan-2,5-dione
- Cas Number:
- 93642-68-3
- Molecular formula:
- C13H24O6Si
- IUPAC Name:
- 3-[3-(triethoxysilyl)propyl]dihydrofuran-2,5-dione
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: HARLAN WINKELMANN, Gartenstr. 27, 33178 Borchen, SPF breeding colony
- Age at study initiation: 6-10 weeks
- Weight at study initiation: male: 184-210 g; female: 174-187 g
- Fasting period before study: withdrawal of food from about 16 hours before to 3-4 hours after treatment
- Housing: macrolon cages (type 4) on soft wood granulate in groups of 5 animals
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): 50 ± 20%
- Air changes (per hr): fully air-conditioned room
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil (Oleum sesami DAB 10)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20% solution
- Amount of vehicle (if gavage): 10 ml/kg bw
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/kg bw - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: symptoms recorded twice daily (morning and afternoon), only once on weekends and public holidays; weighed weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No deaths occurred during the whole study.
- Clinical signs:
- other: Squatting posture, irregular respiration, stilted and uncoordinated gait. Impairment of motility and respiration - reversible after 1 day.
- Gross pathology:
- Narrowed palpebral fissure. No macroscopically visible changes at necropsy.
Any other information on results incl. tables
Table 1: Mean body weights
Dose |
Mean body weight (g) on day |
|||||
Substance mg/kg bw |
1 |
8 |
15 |
1 |
8 |
15 |
Males |
females |
|||||
2000 |
209 |
262 |
315 |
187 |
216 |
228 |
2000 |
184 |
226 |
252 |
174 |
203 |
221 |
2000 |
210 |
278 |
315 |
176 |
204 |
220 |
2000 |
196 |
259 |
288 |
179 |
205 |
222 |
2000 |
196 |
240 |
275 |
187 |
232 |
257 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Dihydro-3-[3-(triethoxysilyl)propyl]furan-2,5-dione has been tested in an acute oral toxicity study conducted according to OECD 401 and in compliance with GLP. The test substance was diluted with sesame oil prior to administration of 2000 mg/kg bw by gavage to 5 male and 5 female rats. The animals showed impairments of motility and respiration as well as narrowed palpebral fissure. Symptoms were reversible 1 day after application. No mortalities occurred. The LD50 was determined to be >2000 mg/kg bw.
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