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EC number: 943-366-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
As the substance is classified as corrosive to skin, no acute toxicity studies need to be conducted. The hazard assessment is based on the available data on the most hazardous constituents of the substance, acetic anhydride and the hydrolysis products, acetic acid and adipic acid.
Oral:
The oral LD50 (rat) is 1780 mg/kg bw for acetic anhydride
The oral LD50 (rat) is 3310 mg/kg bw for acetic acid
The oral LD50 (mouse) is 1900 mg/kg bw for adipic acid
Inhalation:
The inhalation LC50 (rat) is 1680 mg/m3 for acetic anhydride
The inhalation LC50 (rat) is 2248 mg/m3 for acetic acid
The inhalation LC50 (rat) is > 7700 mg/m3 for adipic acid
Dermal:
No data available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 780 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1 680 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The weight of evidence approach is used to assess the acute toxicity of the target substance. No studies are conducted for the target substance since it is classified for corrosive to skin. The substance is composed of acetic anhydride (typical conc. ca. 7 wt. %), adipic acid, di-anhydride with bis (acetic acid) (typical conc. ca. 57 wt. %) and acetic acid (typical conc. ca. 33 wt. %). The main and the most hazardous component of this substance is acetic anhydride which has well-known corrosive and irritating effects on the eyes, skin and respiratory tract.Since acetic anhydride readily hydrolyzes to acetic acid in water (half-life about 4 minutes), systemic toxicity is unlikely. As adipic acid anhydride is hydrolytically unstable information on adipic acid is used in the assessment as well.
Oral exposure
There are few studies via oral route available from acetic anhydride, acetic acid and adipic acid. The acute oral toxicity value (LD50; rat) for acetic anhydride is 1 780 mg/kg bw (OECD; SIDS, 1997). The oral LD50 for acetic acid is 3 310 and 4 960 mg/kg bw in rats and mice, respectively (Woodard, G et al., 1941; HSDB, 2016). Furthermore, for adipic acid oral toxicity values are 1 900 mg/kg and 11000 mg/kg in mice and rats (Bingham, E. et al., 2001).
Inhalation
Acetic anhydride: Inhalation LC50was approximately 400 ppm (1 680 mg/m3; rats, 6 hrs, vapor) (OECD; SIDS, 1997). In this two-week inhalation study, rats were exposed for 6 hrs/day, 5 days per week (or less) to 25, 100 or 400 ppm acetic anhydride vapor. Mortality (40%) was observed in the 400 ppm (1680 mg/m3) group after the first 6-hr. exposure period. In the study by Smyth et al., 1951 rats were exposed to 1000 ppm and 2000ppm concentration of acetic anhydride for 4 hours. Mortality of 0% and 100% was observed at 1000 ppm (4240 mg/m3) and 2000 ppm (8480 mg/m3), respectively.
Acetic acid: The LC50 for mice was found to be 5 620 ppm (2 248 mg/m3) for 1-hour exposures. Symptoms were mainly irritation of the upper respiratory tract and of the conjunctiva. Most of the surviving animals recovered quickly and showed no abnormal condition after 30–35 hours (HSDB, 2016)
Adipic acid: In a study similar to OECD TG 403, neither mortality, toxic symptoms nor macroscopic pathological changes were observed in 20 rats exposed for 4 hours (nose only) to the maximal attainable concentration of 7700 mg/m3 of adipic acid (99.8 %) dust (OECD; SIDS, 2004).
Justification for selection of acute toxicity – oral endpoint
No study was selected since hazard assessment is based on WoE from the studies conducted for acetic anhydride, acetic acid and adipic acid.
Justification for selection of acute toxicity – inhalation endpoint
No study was selected since hazard assessment is based on WoE from the studies conducted for acetic anhydride, acetic acid and adipic acid.
Justification for classification or non-classification
The target substance will be classified for Acute tox. 4 H302 (oral) and Acute tox. 4 H332 (inhalation)according to CLP Regulation 1272/2008.This is line with the harmonized classification of the most hazardous component (acetic anhydride) of the target substance.
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