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Administrative data

Description of key information

LD50 was estimated to be 1000 mg/kg bw on mouse for substance m-Methoxyacetophenone.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Principles of method if other than guideline:
Data is predicted using the Danish (Q)SAR Database
GLP compliance:
no
Test type:
standard acute method
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: estimated
Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 1000 mg/kg bw on mouse for substance m-Methoxyacetophenone . Thus based on this value it can be concluded that the substance can be classified in Acute toxicity Category IV as per the criteria of CLP regulation.
Executive summary:

Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 1000 mg/kg bw on mouse for substance m-Methoxyacetophenone . Thus based on this value it can be concluded that the substance can be classified in Acute toxicity Category IV as per the criteria of CLP regulation.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
1 000 mg/kg bw
Quality of whole database:
Data is of Klimish 2 and prediction id done using Danish (Q)SAR Database

Additional information

Acute oral:

Based on the QSAR prediction done using the Danish (Q)SAR Database, the LD50 was estimated to be 1000 mg/kg bw on mouse for substance m-Methoxyacetophenone.

On the basis of Danish (Q) SAR Database (2016), the LD50 was estimated to be 1500 mg/kg bw on rat for substance m-Methoxyacetophenone.

In a study conducted for read across by Schaferet al.(1985), acute oral toxicity was evaluated in deer mice by using 3-Acetylphenol in by oral for 3 days. 50% Mortality was observed at a range concentration of 470-1600mg/kg. Therefore, LD50 was considered to be to be 470-1600mg/kg when deer mice treated with 3-Acetylphenol orally.

In a RTECS data base (2016) for read across Ethanone, 1-(3, 5-dimethoxyphenyl), LD 50 value for mouse was found to be > 1000 mg/kg.

Thus, based on this value for m-Methoxyacetophenone(CAS no 586-37-8) and its structurally related read across 3-Acetylphenol (CAS no 121-71-2) and Ethanone, 1-(3, 5-dimethoxyphenyl) (CAS no 39151 -19 -4), it can be concluded that the substance can be classified in Acute toxicity Category IV as per the criteria of CLP regulation.


Justification for selection of acute toxicity – oral endpoint
LD50 was estimated to be 1000 mg/kg bw on mouse for substance m-Methoxyacetophenone.

Justification for classification or non-classification

m-Methoxyacetophenone substance can be classified in Acute toxicity Category IV as per the criteria of CLP regulation.