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Diss Factsheets
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EC number: 930-964-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 01.03.1979 to 29.05.1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test method similar to OECD guideline 401. No GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Method: Internal procedure valid at the time of study.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): Monochloressigsäure
- Physical state: white crystalline flakes
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Own breeding
- Strain: Hoe WISKf (SPF71)
- Weight at study initiation: 162 - 176 g (x = 169 g, s = ± 4.51 g, n = 40).
- Fasting period before study: No food supplied from 16 h prior to administration until 2 h post administration.
- Housing: Animals were housed in groups in plastic cages.
- Diet (e.g. ad libitum): Altromin 1324 (Altromin GmbH, Lage/Lippe, Germany, ad libitum.
- Water (e.g. ad libitum): Tap water, ad libitum.
The test was performed in female rats, because in preliminary tests, a higher sensitivity could be determined.
IN-LIFE DATES: From: 01.03.1979 To: 29/03/1979.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- Stock solution: 1% solution in deionized water (1 g/100 mL).
- Doses:
- 40, 63, 100, 160 mg/kg bw
- No. of animals per sex per dose:
- 10 female rats per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The animals were weighed weekly.
- Necropsy of survivors performed: yes
- Other examinations performed: The symptoms of toxicity, the mortality rate and the death time were recorded. - Statistics:
- LD 50 determined by Probit analysis (method acc to Linder and Weber); confidence limits calculated according to Fieller (company software).
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 90.4 mg/kg bw
- 95% CL:
- 73.6 - 112
- Mortality:
- Animals died between 128 minutes and 24 hours after the administration.
- Clinical signs:
- In dead animals, the following clinical signs were observed: motor restlessness, squat position, hair-raising, balance disorder, prone position, passivity, drowsiness, dilated eyes, increased lacrimation and intermittent respiration.
- Gross pathology:
- Dead animals during the study: livers red-brown, intensively supplied with blood; lungs slightly red to pink; black spleen near stomach joining points
Surviving animals: without macroscopic findings.
Any other information on results incl. tables
Table 07.02.01_01. Mortality rate
Dose (mg/kg bw) | Concentration (%) | Dead animals/ Used animals |
40 | 1 | 0/10 |
63 | 1 | 2/10 |
100 | 1 | 5/10 |
160 | 1 | 10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- At the end of an observation period of 14 days a LD 50 of 90.4 (73.6 - 112) mg/kg body weight was determined by Probit.
- Executive summary:
The study of acute oral toxicity of monochloroacetic acid was performed on female Wistar rats. Test method was similar to OECD guideline 401. A single oral dose of test substance was administered by gavage to ten animals per dose. Four dose levels were tested: 40, 63, 100 and 160 mg/kg bw. At the end of an observation period of 14 days a LD 50 of 90.4 (73.6 - 112) mg/kg body weight was determined by Probit.
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