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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute inhalation toxicity conducted in rat
Author:
IFA GESTIS
Year:
2018
Bibliographic source:
GESTIS

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute inhalation toxicity study of test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: Divinylbenzene- InChI: 1S/C10H10/c1-3-9-7-5-6-8-10(9)4-2/h3-8H,1-2H2- Smiles: C=CC1=CC=CC=C1C=C- Molecular formula :C10H10- Molecular weight :131.1969 g/mole- Substance type:Organic- Physical state:Colorless liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remark on MMAD/GSD:
not specified
Details on inhalation exposure:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Remarks on duration:
not specified
Concentrations:
645 ppm (645000 mg/m3)
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
- Other examinations performed: Animals were observed for mortality and clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
645 000 mg/m³ air
Based on:
test mat.
Exp. duration:
7 h
Remarks on result:
other: 50% mortality was observed
Mortality:
50% mortality was observed at 645000 mg/m3
Clinical signs:
other: Toxic effects were not observed.
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Conclusions:
The acute inhalation toxicity dose (LC50) value was considered to be 645 ppm (645000 mg/m3), when rats were exposed with test chemical via inhalation route by vapors for 7 hrs.
Executive summary:

Acute Inhalation toxicity study was conducted by using test chemical in rats at the concentration of 645 ppm by inhalation route via vapors for 7 hours. Animals were observed for mortality and clinical signs. 50% mortality was observed. Toxic effects were not observed. Hence, LC50 value was considered to be 645 ppm (645000 mg/m3), when rats were exposed with test chemical via inhalation route by vapors for 7 hrs.