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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity by using test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus
Reference Type:
secondary source
Title:
Toxicity Study
Author:
NTRL
Year:
1990
Bibliographic source:
NTRL

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Acute oral toxicity of test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- IUPAC Name: 4-Ethenylphenyl acetate- InChI: 1S/C10H10O2/c1-3-9-4-6-10(7-5-9)12-8(2)11/h3-7H,1H2,2H3- Smiles: O=C(Oc1ccc(cc1)C=C)C- Molecular formula:C10H10O2- Molecular weight :162.187 g/mole- Substance type:Organic- Physical state:Liquid

Test animals

Species:
rat
Strain:
other: CD rat
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS- Age at study initiation: 4 week-old- Fasting period before study: fasted overnight

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
not specified
Doses:
700, 1000, 1429, 2014 mg/kg
No. of animals per sex per dose:
groups of 5 rats of each sex
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days - Necropsy of survivors performed: yes, survivors were killed and necropsied.- Other examinations performed: Animals were observed for mortality and clinical signs.
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 732 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
LD50
Effect level:
1 503 mg/kg bw
Based on:
test mat.
Sex:
female
Dose descriptor:
LD50
Effect level:
2 027 mg/kg bw
Based on:
test mat.
Mortality:
Mortality occurred within 3 days of administration.
Clinical signs:
Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity.
Body weight:
not specified
Gross pathology:
Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining.
Other findings:
not specified

Any other information on results incl. tables

Table

DOSAGE

mg/kg

MORTALITY

COMMENTS

Males

Females

700

0/5

0/5

Minimal Effects

1000

1/5

0/5

Survivors appeared normal after day 5

1429

2/5

2/5

 

2014

4/5

2/5

Cause of death not determined

 

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
Acute oral toxicity dose (LD50) value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.
Executive summary:

Acute oral toxicity study was conducted by using test chemical in groups of 5 CD rats of each sex at the dose concentration of 700, 1000, 1429, 2014 mg/kg bw. The test chemical was dissolved incorn oil and administered via oral gavage route. Animals were observed for mortality and clinical signs for 14 days after administration of the test substance and survivors were killed and necropsied. Decedents were necropsied as soon as possible after death. Mortality occurred within 3 days of administration. Clinical signs at dose levels of 1000 mg/kg and above were severe but did not suggest any specific mechanism of toxicity. Necropsy of decedents revealed altered stomach contents and occasionally dark thymus, dark areas on the gastric mucosa and body surface staining. Hence, LD50 value was considered to be 1732 mg/kg in both male and female; 1503 mg/kg in males; and 2027 mg/kg in females, when groups of 5 CD rats of each sex were treated with test chemical via oral gavage route.