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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxikologische Untersuchung einiger in der ungarischen Industrie zur Anwendung gelangenden aromatischen Amidoverbindungen
Author:
Sziza, M. and Podhragyai, L.
Year:
1957
Bibliographic source:
Archiv fuer Gewerbepathologie und Gewerbehygiene 15, 447-456 (1957)
Reference Type:
other: Authoritative data base
Title:
GCID 512735
Author:
ACToR Database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):- Sziza, M. and Podhragyai, L.: Archiv fuer Gewerbepathologie und Gewerbehygiene 15, 447-456 (1957)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Induction exposure by dermal application of a 10 % solution of N,N-diethylaniline; challenge exposure by dermal application of 1 or 2 % solutions of the test substance
GLP compliance:
not specified
Type of study:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: N,N-diethylaniline
- Substance type: Organic
- Physical state: Liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: Dermal
Vehicle:
other: Acetone
Concentration / amount:
10% (induction) and 1 or 2 % (challenge)
Challengeopen allclose all
Route:
other: Dermal
Vehicle:
other: Acetone
Concentration / amount:
10% (induction) and 1 or 2 % (challenge)
No. of animals per dose:
no data

Results and discussion

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test group
Dose level:
10% (induction) and 1 or 2 % (challenge)
Clinical observations:
Not Sensitizing
Remarks on result:
other: Reading: 1st reading. Group: test group. Dose level: 10% (induction) and 1 or 2 % (challenge). Clinical observations: Not Sensitizing.

Any other information on results incl. tables

Not Sensitizing

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No sensitization was reported from the Induction exposure by dermal application of a 10 % solution of N,N-diethylaniline; and challenge exposure by dermal application of 1 or 2 % solutions of N,N-diethylaniline
Executive summary:

No sensitization was reported from the Induction exposure by dermal application of a 10 % solution of N,N-diethylaniline; and challenge exposure by dermal application of 1 or 2 % solutions of N,N-diethylaniline