Malonic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Jan 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Principles of method if other than guideline:

Particle Size Measurement1. Scope1.1This method is applicable to substances with a particle size of less than 250 microns2. Principle2.1The method relies on shaking sieves a various apertures.3. Reagents3.1No reagents are needed.4. Apparatus4.1 Sieves of 250 and 60 µm 4.2 Analytical balance. 5. Procedure5.1Stack the sieves and place on the top sieve a weigh of the substance or material to be tested.5.2 Shake the sieves with a left to right motion for 5 minutes. 5.3 Weigh the material retained on each sieve to 2 decimal places6. Calculation6.1The weight retained on each sieve if expressed as a % of the total initial weight of the substance being tested. 7. Report7.1Report each fraction retained by each sieve expressed as % of the total +/- 2 x SD.

GLP compliance:

no

Type of method:

sieving

Type of particle tested:

primary particle

Type of distribution:

mass based distribution

Specific details on test material used for the study:

Batch number of test material: 20160723

Percentile:

other: 72.71%

Mean:

> 250 µm

St. dev.:

0.008

Percentile:

other: 25.13%

Mean:

> 63 µm

St. dev.:

0.005

Percentile:

other: 0.86%

Mean:

> 0 - < 63 µm

St. dev.:

0.001

Sieve µm	Wt in grams	Mean	SD	2xSD	CV %
250	36.24
	36.38
	36.49
	36.22
	36.33
	36.46
	36.38
	36.47
	36.41
	36.29	36.37	0.00801	0.01602	72.71
63	12.63
	12.55
	12.61
	12.58
	12.69
	12.63
	12.51
	12.44
	12.53
	12.62	12.58	0.00475	0.00950	25.15
< 63	0.44
	0.41
	0.48
	0.39
	0.45
	0.39
	0.42
	0.46
	0.43
	0.44	0.43	0.00077	0.00154	0.86

Conclusions:

The particle size was found to be > 250 micron. An assessment of the dust content was made on the basis of particles passing through a 63 micron sieve. The amount by weight of particles of less than 63 microns was 0.86 %.

Executive summary:

The particle size was found to be > 250 micron. An assessment of the dust content was made on the basis of particles passing through a 63 micron sieve. The amount by weight of particles of less than 63 microns was 0.86 %.

Description of key information

The particle size was found to be > 250 micron. The amount by weight of particles of less than 63 microns was 0.86 %.