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Diss Factsheets
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EC number: 215-656-5 | CAS number: 1337-83-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Compilation of Historical Local Lymph Node Data for evaluation of skin sensitization Alternative Methos
- Author:
- G. Frank Gerberick, Cindy A. Ryan, Petra S. Kern, Harald Schlatter, Rebecca J. Dearman, Ian Kimber, Grace Y. Patlewicz, and David A. Basketter
- Year:
- 2 005
- Bibliographic source:
- Dermatitis, Vol 16, No. 4 (December), 2005: pp 157-202
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Principles of method if other than guideline:
- In vivo skin sanitization toxicity study of trans -2-Decenal in female mice
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 2-decenal
- EC Number:
- 223-472-1
- EC Name:
- 2-decenal
- Cas Number:
- 3913-71-1
- IUPAC Name:
- dec-2-enal
- Reference substance name:
- trans -2-Decenal
- IUPAC Name:
- trans -2-Decenal
- Details on test material:
- - Name of test material (as cited in study report): trans -2-Decenal
- Molecular formula (if other than submission substance): C10H18O
- Molecular weight (if other than submission substance): 154.2512 g/mole
- Substance type: Organic
- Physical state: No data available
- Purity No data available
- Impurities (identity and concentrations): No data available
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: No data available
- Age at study initiation: 7-12 weeks
- Weight at study initiation: No data available
- Housing: No data available
- Diet (e.g. ad libitum): No data available
- Water (e.g. ad libitum): No data available
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To No data available
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25 μl
- No. of animals per dose:
- No data available
- Details on study design:
- RANGE FINDING TESTS: No data available
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: 3 day
- Test groups: 1
- Control group: 1
- Site: Dorsum of Both ears
- Frequency of applications: Once daily
- Duration: 3 day
- Concentrations: 25 μl
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: Five days
- Exposure period: Once
- Test groups: 1
- Control group: 1
- Site: Tail
- Concentrations: 250 μL
- Evaluation (hr after challenge): 5 hours
OTHER: No data available - Positive control substance(s):
- other: Phosphate-buffered saline
- Statistics:
- A substance was classified as a skin sensitizer if, at one or more test concentration, it induced a threefold or greater increase in local lymph node proliferative activity when compared with concurrent vehicle – treated control (SI, ≥ 3).
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- other: Migrated information from in vivo LLNA study
- Remarks on result:
- other: Reading: other: calculated. Group: test group. Dose level: 25 μl . Clinical observations: Moderate sensitizer .
- Parameter:
- SI
- Remarks on result:
- other: 9.5
Any other information on results incl. tables
Chemical structure, Physicochemical Parameters, LLNA data, and Potency Categorization
Chemical structure, |
CAS no. |
Log KP |
Log kow |
MW |
Vehicle |
LLNA % |
LLNA% |
LLNA% |
LLNA% |
LLNA% |
LLNA% |
LLNA SI |
LLNA SI |
LLNA SI |
LLNA SI |
LLNA SI |
LLNA SI |
LLNA SI |
LLNA EC3*(%) |
3913-71-1 |
-1.86 |
2.54 |
154.25 |
AOO |
0.5 |
1.0 |
2.5 |
5.0 |
10.0 |
- |
1.3 |
1.1 |
3 |
6 |
9.5 |
- |
2.5 |
Moderate |
AOO = acetone olive oil (4:1); CAS = Chemical Abstrac service number; Kow = octenol water partition coefficient (log scale); Kp=skin penetration coefficient (log scale); LLNA= local lymph node assay
*Mathematically estimated concentration of test chemical necessary to induce a threefold stimulation index (SI)
Classification of relative skin sensitization potency by Local Lymph Node Assay EC3 values
EC3 values (%) |
Potency Classification |
≥ 10 to ≤ 100 |
Weak |
≥ 1 to ≤ 10 |
Moderate |
≥ 0.1 to ≤ 1 |
Strong |
< 0.1 |
Extreme |
Log kow (Log P) Distribution of Allergens by Potency Classification
Log kow rang |
Skin penetration |
Allergen Potency* Distribution |
< - 3 |
Very poor skin permeant, very hydrophobic |
0 |
≥- 3 to -1 |
Poor skin permeant, hydrophobic |
4 (2E, 1S, 0M, 1W) |
≥- 1 to 3 |
Very good skin permeant, amphiphilic |
113 (7E, 17S, 54M, 35W) |
≥ 3 to 5 |
Good skin permeant, slightly lipophilic |
43 (2E, 3S, 11M, 27W) |
≥ 5 |
Moderate skin permeant but decreasing with increasing log kow |
9 (2E, 0S, 4M, 3W) |
Molecular weight Distribution of Allergen Potency
MW rang |
Allergen Potency* Distribution |
< 100 |
10 (0E, 2S, £M, %W) |
≥100 to 200 |
89 (5E, 11S, 45M, 28W) |
≥ 200 to 300 |
45 (7E, 4S, 12M, 22W) |
≥ 300 to 400 |
23 (1E, 3S, 8M, 11W) |
≥ 400 |
2 (0E, 1S, 1M, 3W) |
MW= molecular weight
*Designated as E (extreme), S (strong), M (moderate), W (weak)
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- trans -2-Decenal was found to be moderate sensitizer to CBA female mice when threefold stimulation index (SI) of trans -2-Decenal was mathematically estimated.
- Executive summary:
trans-2-Decenal was found to be moderate sensitizer to CBA female mice when threefold stimulation index (SI) of trans-2-Decenal was mathematically estimated.
Hence, trans-2-Decenal was classified as moderate sensitizer
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