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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

Based on inhibition in growth of test strain Salmonella choleraesuis subsp. choleraesuis ATCC 35640, the MIC value was found to be 12.5 mg/l.
And the test compound 2E-Undecenal did not show any antibacterial activity of test bacterial strain E. coli, E. aerogenes, P. aeruginosa and P. vulgariis, at a conc. upto 800 mg/l, respectively. Thus, the MIC value for these bacterial strains can be found to be greater than 800 mg/l.

Key value for chemical safety assessment

Additional information

Various studies for the target chemical Undecenal (Cas no.1337-83-3) along with read across substance data were reviewed to summarize the following information:

The peer reviewed journal study from Journal (ISAO KUBO et al;Agricultural and Food Chemistry, Vol. 52(11), Pg. no. 3329–3332, Jun 2, 2004)study indicate that toxicity to micro-organisms study was conducted onSalmonella choleraesuis subsp. choleraesuisATCC35640,E. coliATCC 9673,Enterobacter aerogenesATCC 13048,Pseudomonas aeruginosaATCC 10145, andProteusVulgarisATCC 13315 for 24 hrs. Broth dilution method was used for the antibacterial assay.

The test chemical solution was prepared by dissolving the test substance in N,N-dimethyl formamide (DMF). The highest conc. of test chemical used for the study was 1600 mg/l. The test bacterial strainswere precultured in 3 ml of NYG broth without shaking at 37°C for 16 h. This preculture was used for the antibacterial assay. The minimum inhibitory concentration (MIC) was determined as the lowest conc. of the test compound that demonstrated no visible growth.

The MBC was also determined. After the determination of MIC, 100-fold dilutions with drug-free NYG broth from each tube showing no turbidity were incubated at 37°C for 48 hrs. After 48 hrs, the MBC was calculated. MBC was defined as the lowest conc. of the test compound that showed no visible growth in the drug-free cultivation.

  Based on inhibition in growth of test strainSalmonella choleraesuis subsp. choleraesuisATCC35640, the MIC value was found to be 12.5 mg/l.

 And the test compound 2E-Undecenal did not show any antibacterial activity of test bacterial strainE. coli, E. aerogenes, P. aeruginosaandP. vulgariis,at a conc. upto 800 mg/l, respectively. Thus, the MIC value for these bacterial strains can be found to be greater than 800 mg/l.

Other scientific journal (Kubo et al; Journal of Applied Microbiology, Vol. 96, Pg. no. 693–699, 2004.)Indicate that inhibition in growth of test organism Salmonella choleraesuis subsp. choleraesuis ATCC 35640, the MIC value was found to be 12.5 mg/l.

Another experimental study (J. Agric. Food Chem., Vol. 51, Pg. on. 3951-3957, 2003) also indicate that the inhibition of test substance 2E-Undecenal in growth of test organismSaccharomyces cerevisiaeATCC 7754, the MIC and MFC value was found to be 6.25 mg/l by Broth macrodilution method.

Read across substance trans-2-decenal (Cas no. 3913-81-3)also showed the antimicrobial effects on Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa micro organism which is at lowest concentration tested 4000 mg/l (4%) significantly inhibited and Increasing the concentration to 40000 mg/l (40%) completely inhibited the growth of all three microorganisms.(Steven Sagun et al; J Pharmacogn Nat Prod. 2016 August ; 2(3): . doi:10.4172/2472-0992.1000119)

Thus all experimental studies for target substance Undecenal (Cas no.1337-83-3) and read across chemical trans-2-decenal (Cas no. 3913-81-3) indicate that the test chemical have tendency to inhibit the growth of microorganisms.