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EC number: 204-254-5 | CAS number: 118-47-8
This study attributed that the differences of offspring weight between the control and low-dosed groups were caused not by tartrazine treatment but by the body size at birth.
A sub chronic study was conducted for Tartrazine in male swiss albino mice for 13 weeks.They were administrated Tartrazine at the concentration of 0, 0.1%, 1% and 2.5% (173.9 ±0.25, 1767.8±0.32and 5541.4±0.47 mg/kg/day ) by oral drinking water. Groups of Tartrazine treated mice, six males per dose group, were mated 1:1 with untreated females for 1 week. Females were then separated and allowed to gestate to term. For females that failed to deliver a litter, this was considered as a sign of male infertility whereas litter delivery indicated male fertility. Food and water consumption, body weight, reproductve fuction, Reproductive performance, organ weight and histopathology were observed. Decrase in food consumption and increase in water consumption were observed in 173.9, 1767.8 and 5541.4 mg/kg/day treated male rats as compared to control. Average (±SE) tartrazine intake calculated from liquid consumption, in mg kg-1day-1, was (173.9±0.25), (1767.8±0.32), (5541.4±0.47) for 0.1, 1 and 2.5% tartrazine groups, respectively. Significantly increased body weight gain was observed in 1767.8 mg/kg/day and decrease in relative testis and seminal vesicles weight in 173.9, 1767.8 and 5541.4 mg/kg/day treated male rats, but the effect were not statistically significant and no effect on absolute organ weight were observed in treated male rats as compared to control. Decreased in male mating index and body weight and litter sizes were observed in 5541.4 mg/kg/day treated male rats as compared to control. Similarly, significant decreased in Total number of spermatids count, Sperm concentration in epididymis reserves and percentage motility in 5541.4 mg/kg/day, percentage motility and Sperm concentration in epididymides in 1767.8 mg/kg/day and Sperm concentration in epididymides in 173.9 mg/kg/day treated male rats as compared to control. Sperm head (amorphous, macro-or microcephaly) and the sperm flagellum (entangled, twisted, coiled, with ANSA) morphological abnormalities and significantly affected percentage morphologically normal spermatozoa were observed in 5541.4 mg/kg/day treated male rats as compared to control. In addition, extensive disruption in semniferous tubules, widening of the interstitial spaces and loss leydig cells, Spermatogenic cells are affected and then depleted with absence of spermatozoa in the lumen at 5541.4 mg/kg/day, decreased intercellular connections and imperfect and dilation in some semniferous tubules of testis at 1767.8 mg/kg/day and emniferous tubules were not identical with conjunctive tissue dystrophy in testes at 173.9 mg/kg/day treated male rats as compared to control. Therefore NOAEL was considered to be173.9 mg/kg/day (0.1%) when swiss albino male mice treated with tartrazine orally by drinking water for 13 weeks.
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