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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from Chemidplus report

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Chemidplus report for CAS 118-47-8
Author:
U.S.national library of medicine
Year:
2016
Bibliographic source:
ChemIDplus,A TOXNET DATABASE, Last updated: 21 June 2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: The data is from chemid plus
Principles of method if other than guideline:
Acute oral toxicity of chemical Pyrazolone T was determined.
GLP compliance:
not specified
Test type:
other: not reported

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material: 5-Oxo-1-(4-sulphophenyl)-2-pyrazoline-3-carboxylic acid
- Molecular formula: C10H8N2O6S
- Molecular weight: 284.2472 g/mol
- Smiles notation: c1cc(ccc1N2C(=O)CC(=N2)C(=O)O)S(=O)(=O)O
- InChl: 1S/C10H8N2O6S/c13-9-5-8(10(14)15)11-12(9)6-1-3-7(
4-2-6)19(16,17)18/h1-4H,5H2,(H,14,15)(H,16,17,18)
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
No data available
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 22 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Lethality of test chemical
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.
Executive summary:

Acute oral toxicity test was conducted on rat to evaluate the lethargic concentration of chemical Pyrazolone T.

The lethal concentration was found to be >22000 mg/kg in acute oral toxicity test of chemical Pyrazolone T exposed to rat by oral route.