Registration Dossier
Registration Dossier
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EC number: 259-915-0 | CAS number: 55947-46-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Determiniation of skin irritation for Methallyl sulfonate
- Author:
- IUCLID dataset
- Year:
- 2 000
- Bibliographic source:
- EUROPEAN COMMISSION European Chemicals Bureau 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Asentioned below
- Principles of method if other than guideline:
- Skin irritation study of Methallyl sulfonate was conducted in 6 male rabbits to determine its irritation potential.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methallyl sulfonate
- IUPAC Name:
- Methallyl sulfonate
- Reference substance name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- EC Number:
- 216-341-5
- EC Name:
- Sodium 2-methylprop-2-ene-1-sulphonate
- Cas Number:
- 1561-92-8
- IUPAC Name:
- sodium 2-methylprop-2-ene-1-sulfonate
- Reference substance name:
- 216–341–5
- IUPAC Name:
- 216–341–5
- Test material form:
- other: Solid
- Details on test material:
- - Name of test material (as cited in study report): sodium 2–methylprop–2–ene–1–sulphonate
- Molecular formula:C4H8O3S.Na
- Molecular weight : 158.152 g/mol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 Hours
- Observation period:
- 48 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: Back
- % coverage: No Data Available
- Type of wrap if used: bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No Data Available
- Time after start of exposure:
No Data Available
SCORING SYSTEM: No Data Available
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: Redness
- Basis:
- mean
- Time point:
- other: 1-2 and 48 hours
- Score:
- 0.17
- Remarks on result:
- other: Non irritant
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 1-2 and 48 hours
- Score:
- 0.25
- Remarks on result:
- other: Non irritant
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material Methallyl sulfonate (CAS No:- 1561-92-8) was found to be non irritant to the rabbits’ skin
- Executive summary:
The skin irritation study ofMethallyl sulfonate(CAS No:-1561-92-8)was performed in rabbits to determine its irritation potential.0.5 ml of the undiluted test substance was applied to the shaved back skin of 6 male rabbits. After occlusion for 24 hours, the bandage was removed. Skin reactions were scored 1–2 and 48 hours after removal of the bandage.Since no irritation was noted ,the test material Methallyl sulfonate(CAS No:-1561-92-8) was found to be non irritant on rabbits’ skin.
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