Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Monographs on fragrance raw materials: Hydratropic aldehyde
Author:
D.L.J Opdyke
Year:
1975
Bibliographic source:
Food and Cosmetics Toxicology ; Volume 13, Issue 5, October 1975, Pages 548

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity study was carried out in rabbits.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Hydratropaldehyde
EC Number:
202-255-5
EC Name:
Hydratropaldehyde
Cas Number:
93-53-8
Molecular formula:
C9H10O
IUPAC Name:
hydratropaldehyde
Constituent 2
Reference substance name:
2 Phenylpropanal
IUPAC Name:
2 Phenylpropanal
Details on test material:
- Name of test material (as cited in study report): Hydratrophic Aldehyde (2 Phenylpropanal)
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Type of coverage:
not specified
Vehicle:
unchanged (no vehicle)
Duration of exposure:
no data
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In an acute dermal study in rats, the acute dermal LD50 for Hydratrophic aldehyde (2 Phenyl propanal) was found to be greater than 5000 mg/kg
Executive summary:

Acute Dermal study was carried out in rabbits.

The test chemical was applied onto the skin of rabbits.

The acute dermal LD50 for Hydratrophic aldehyde (2 Phenyl propanal) was found to be greater than 5000mg/kg.

Based on value the chemical was not classified as per CLP regulations.

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