7-[[2-[(aminocarbonyl)amino]-4-[[4-chloro-6-[[4-[vinylsulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]phenyl]azo]naphthalene-1,3,6-trisulphonic acid, sodium salt

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

ECOSAR v1.1

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

7 848.481 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: Neutral Organic SAR: Baseline toxicity

Validity criteria fulfilled:

not specified

Conclusions:

Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 48 hours EC50 was estimated to be 7848.481 mg/L on Daphnia Magna for substance 7-[[2-[(aminocarbonyl)amino]-4-[[4-chloro-6-[[4-[vinylsulphonyl]phenyl]amino]-1,3,5-triazin-2-yl]amino]phenyl]azo]naphthalene-1,3,6-trisulphonic acid, sodium salt with immobilization effects. Thus based on this value it can be concluded that the substance can be classified as not hazardous as per the criteria of CLP regulation.

Executive summary:

Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.1,

48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compound 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt (CAS no 94158-80-2) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt was estimated to be 7848.481 mg/l on the basis of mobility. 

Based on the result the chemical was considered as not classified as per CLP regulations.

Description of key information

The predicted data suggests the effective concentration (EC50) for the test compound 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt was estimated to be 7848.481 mg/l on the basis of mobility. 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

7 848.481 mg/L

Additional information

Various predicted studies and read across study for the 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt were reviewed to summarize the following information: 

48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt (CAS no 94158-80-2) and the results were predicted. The study was based on the effects of the 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt was estimated to be 65.576499939 mg/Lon the basis of mobility.

 

48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compound 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt (CAS no 94158-80-2) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt was estimated to be 7848.481 mg/l on the basis of mobility. 

 

As in vitro experiment for read across CAS suramin (145 -63 -1) (Teresa Santamarina, Florencio M Ubeira, José Manuel Leiro, Manuel Luis Sanmartín Durán, Bull. Eur.Ass Fish path 13(2), 45, 1993) was performed on 8 Gyrodactvlus (worm) were taken from fish and placed in petri dish with added suramin and observed for 30 and 60 min after exposing to the suramin. A control trial was also used were zero mortality observed. After exposure period only 1 worm death was observed.On the basis of this, the LD 50 value for aquatic invertebrates for suramin (145-63-1) was determined to be greater than 200 mg/l as 1 worm was died out of 8 used for experiment

 

Based on the result of SSS QSAR prediction model the test chemical was classified as chronic category 3 but as the test chemical was log Kow value 0.48 which was less than 4. On the basis of this the 1,3,6-Naphthalenetrisulfonic acid, 7-(2-(2-((aminocarbonyl)amino)-4-((4-chloro-6-((4-(ethenylsulfonyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)phenyl)diazenyl)-, sodium salt was considered as not classified as per QSAR prediction,EPI suite,2016, read across study and also according to the CLP regulations.