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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

FC-72 is not expected to be toxic to activated sludge at the limit of water solubility by readacross from category members.  Activated sludge EC50s were >1000 mg/L (nominal) in valid tests of perfluoroheptanes (FC-84), perfluoromethyl morpholine (FC-3284), and FC-770.  These category member results are considered applicable to FC-72.

Key value for chemical safety assessment

Additional information

FC-72 is a member of the Perfluorinated Organic Chemicals, C5-C18 category. Because these substances exhibit similarity in their physicochemical properties and toxicological properties in mammals, and because available data indicates that parent molecules are not reactive toward biological molecules and cannot undergo bioactivation by normal enzymatic processes, they can be considered members of a chemical category. Data gaps for ecological toxicity can therefore be addressed by read-across and/or trend analysis between category members. Reliable studies are available for sludge toxicity of category members perfluoroheptanes (FC-3284), perfluoromethyl morpholine (FC-3284), and FC-770. In all cases, 3-hour EC50s were in excess of 1000 mg/L (nominal concentation). Further support for lack of toxicity is provided by the results of Microtox ® tests with FC-43 and with FC-84. In both cases, less than 50 percent effect (inhibition of fluorescence) was seen with saturated solutions. Two remaining studies were methodologically flawed and are not considered further. Please see IUCLID section 13 for the category justification and a matrix of aquatic toxicity data for members of the Perfluorinated Organic Chemicals C5-C18 category.