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Administrative data

Endpoint:
chronic toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: English summary of a Russian non-guideline study. No or very limited information on design and methods of the study.

Data source

Reference
Reference Type:
secondary source
Title:
Pathomorphology of the central nervous system during the chronic poisoning of rats with α-picoline
Author:
Polilei, S.A.
Year:
1969
Bibliographic source:
Tr.Krasnoyarsk Gos. Med. Inst. 9(1), 80-85, 1969 (Russ) cited in Chem.Abstr, Vol 75

Materials and methods

Principles of method if other than guideline:
The test substance was given orally for 6 month to rats. After the exposure period, animals were decapitated. Brain and spinal cord were examined histopathologically.
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Details on test material:
- Name of test material (as cited in study report): α-picoline

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified
Duration of treatment / exposure:
6 months
Doses / concentrations
Remarks:
Doses / Concentrations:
0.0025, 0.01 or 0.05 mg/kg bw
Basis:
no data
Control animals:
no

Examinations

Sacrifice and pathology:
Brain and spinal cord were examined histopathologically

Results and discussion

Results of examinations

Details on results:
- Functional and dystrophic changes in cells of the 1st, 2nd, 3rd, and 5th layer of the cerebral cortex, but also of the sub-cortex were observed. At the dose of 0.0025 mg/kg bw these changes were mostly functional but single neurons of the thalamo-hypothalamnic region showed swelling, chromatolysis, wrinkling, and hyperchromatosis.
- By raising the dose of the test substance, dystrophic changes in all parts of the brain increase, and become most pronounced in the 3rd group of rats.
- Chronic intoxication of animals with the test substance is accompanied by vascular disturbances aggravating neuronal and glial lesions. Chronically intoxicated rats of the 3rd group showed a relatively constant demyelination of nerve pathways in the brain.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion