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Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to birds: acute oral toxicity test
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented publication which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
The Acute Oral Toxicity, Repellency, and Hazard Potential of 998 Chemicals to One or More Species of Wild and Domestic Birds
Author:
Schafer et al.
Year:
1983
Bibliographic source:
Arch. Environm. Contam. Toxicol. 12, 355-382 (1983)

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more of 68 species of wild and domestic birds was determined by standardized testing procedures.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Details on test material:
- Name of test material (as cited in study report): 2-Methylpyridine
Dose method:
gavage
Analytical monitoring:
not specified
Vehicle:
yes
Details on preparation and analysis of diet:
Dosed by gavage with solutions or suspensions of the test chemical in propylene glycol.


Test organisms

Test organisms (species):
other: Sturnus vulgaris (European Starling), Agelaius phoeniceus (Redwinged blackbird), Coturnix coturnix (Coturnix Quail)
Details on test organisms:
Dosed by gavage with solutions or suspensions of the test chemical in propylene glycol.

Study design

Limit test:
no
Details on test conditions:
ACCLIMATION
- Acclimation period: preconditioned to captivity for 2 to 6 weeks

METHOD OF REPELLENCY TEST
- Repellency tests were conducted by the methods of Starr et al., 1964 and Schafer and Brunton, 1971.


Examinations

Reference substance (positive control):
not specified

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Conc. / dose based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: The same LD50 value for all three tested bird species
Repellency factors (if applicable):
It was not possible to calculate the repellency factor with the available data. The R50 for Red-winged blackbirds was + 1.00 (%) and the LD50> 1000 mg/kg.

Applicant's summary and conclusion