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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature available

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1997

Materials and methods

Principles of method if other than guideline:
other: micronucleus assay in mice
Type of assay:
micronucleus assay

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohex-3-ene-1-carbaldehyde
EC Number:
202-858-3
EC Name:
Cyclohex-3-ene-1-carbaldehyde
Cas Number:
100-50-5
Molecular formula:
C7H10O
IUPAC Name:
cyclohex-3-ene-1-carbaldehyde
Details on test material:
tetrahydrobenzaldehyde

Test animals

Species:
mouse
Strain:
ICR
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Duration of treatment / exposure:
once
Frequency of treatment:
once
Post exposure period:
24, 48 and 72 h after treatment
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 250, 500 or 1000 mg/kg bw
Basis:

No. of animals per sex per dose:
15 per dose and sex (at 1000 mg/kg bw an addtional group of 5 male and 5 female mice dosed with the test substance were designated as replacement animals in the event of mortality prior to the scheduled sacrifice time)
Control animals:
yes

Examinations

Tissues and cell types examined:
bone marrow cells were examined

Results and discussion

Test results
Sex:
male/female
Genotoxicity:
negative
Toxicity:
yes
Vehicle controls validity:
not specified
Negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Executive summary:

The test substance was negative in the in vivo micronucleus assay.