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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: although limited documented sufficient information for assessment

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth, H.F. et al.,
Year:
1962
Bibliographic source:
Am. Ind. Hyg. Ass. J. 23, 95-107

Materials and methods

Principles of method if other than guideline:
Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates, using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . the fur was removed from the entire trunk by clipping and the dose is retainded beneath an imperious plastic film. The animals were immobilized during tge 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period
GLP compliance:
no
Test type:
other: acute dermal toxicity study

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohex-3-ene-1-carbaldehyde
EC Number:
202-858-3
EC Name:
Cyclohex-3-ene-1-carbaldehyde
Cas Number:
100-50-5
Molecular formula:
C7H10O
IUPAC Name:
cyclohex-3-ene-1-carbaldehyde
Details on test material:
4-Cyclohexene-1-carboxaldehyde

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 2.5-3.5 kg
- Fasting period before study:
- Housing: no data
- Diet ad libitum
- Water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
details not given

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates (1944, J Pharmacol Exp Therap 82, 377), using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . The fur was removed from the entire trunk by clipping and the dose is retained beneath an imperious plastic film. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period
Duration of exposure:
24 h
Doses:
no data
No. of animals per sex per dose:
4
Control animals:
no
Details on study design:
Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates (1944, J Pharmacol Exp Therap 82, 377), using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . The fur was removed from the entire trunk by clipping and the dose is retained beneath an imperious plastic film. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period
Statistics:
LD50 was estimated by the method of Thompson (1947) Bacteriol Rev 11, 115 using the tables of Weil (1952) Biometrics 8, 249

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
1 770 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

original value: 1.77 ml/kg; density: 0.967 g/cm3

Applicant's summary and conclusion

Executive summary:

LD50 rabbit: 1712 mg/kg

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