Cyclohex-3-ene-1-carbaldehyde

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: although limited documented sufficient information for assessment

Data source

Reference

Reference Type:

publication

Title:

Range-Finding Toxicity Data: List VI

Author:

Smyth, H.F. et al.,

Year:

1962

Bibliographic source:

Am. Ind. Hyg. Ass. J. 23, 95-107

Materials and methods

Principles of method if other than guideline:

Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates, using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . the fur was removed from the entire trunk by clipping and the dose is retainded beneath an imperious plastic film. The animals were immobilized during tge 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period

GLP compliance:

no

Test type:

other: acute dermal toxicity study

Test material

Test material information

Constituent 1

Reference substance name:

Cyclohex-3-ene-1-carbaldehyde

EC Number:

202-858-3

EC Name:

Cyclohex-3-ene-1-carbaldehyde

Cas Number:

100-50-5

Molecular formula:

C7H10O

IUPAC Name:

cyclohex-3-ene-1-carbaldehyde

Details on test material:

4-Cyclohexene-1-carboxaldehyde

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.5-3.5 kg
- Fasting period before study:
- Housing: no data
- Diet ad libitum
- Water ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
details not given

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates (1944, J Pharmacol Exp Therap 82, 377), using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . The fur was removed from the entire trunk by clipping and the dose is retained beneath an imperious plastic film. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period

Duration of exposure:

24 h

Doses:

no data

No. of animals per sex per dose:

4

Control animals:

no

Details on study design:

Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates (1944, J Pharmacol Exp Therap 82, 377), using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . The fur was removed from the entire trunk by clipping and the dose is retained beneath an imperious plastic film. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period

Statistics:

LD50 was estimated by the method of Thompson (1947) Bacteriol Rev 11, 115 using the tables of Weil (1952) Biometrics 8, 249

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

1 770 mg/kg bw

Based on:

test mat.

Any other information on results incl. tables

original value: 1.77 ml/kg; density: 0.967 g/cm3

Applicant's summary and conclusion

Executive summary:

LD50 rabbit: 1712 mg/kg