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EC number: 202-858-3 | CAS number: 100-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: although limited documented sufficient information for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth, H.F. et al.,
- Year:
- 1 962
- Bibliographic source:
- Am. Ind. Hyg. Ass. J. 23, 95-107
Materials and methods
- Principles of method if other than guideline:
- Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates, using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . the fur was removed from the entire trunk by clipping and the dose is retainded beneath an imperious plastic film. The animals were immobilized during tge 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period
- GLP compliance:
- no
- Test type:
- other: acute dermal toxicity study
Test material
- Reference substance name:
- Cyclohex-3-ene-1-carbaldehyde
- EC Number:
- 202-858-3
- EC Name:
- Cyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 100-50-5
- Molecular formula:
- C7H10O
- IUPAC Name:
- cyclohex-3-ene-1-carbaldehyde
- Details on test material:
- 4-Cyclohexene-1-carboxaldehyde
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5-3.5 kg
- Fasting period before study:
- Housing: no data
- Diet ad libitum
- Water ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
details not given
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates (1944, J Pharmacol Exp Therap 82, 377), using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . The fur was removed from the entire trunk by clipping and the dose is retained beneath an imperious plastic film. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period
- Duration of exposure:
- 24 h
- Doses:
- no data
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Penetration o f rabbits skin is estimated by a technique closely akinto the one-day cuff method of Draize and associates (1944, J Pharmacol Exp Therap 82, 377), using groups of 4 male albino New Zealand rabbits weighing 2.5 to 3.5 kg . The fur was removed from the entire trunk by clipping and the dose is retained beneath an imperious plastic film. The animals were immobilized during the 24-hour contact period, after which the film was removed and the rabbits are caged for subsequent 14 day observation period
- Statistics:
- LD50 was estimated by the method of Thompson (1947) Bacteriol Rev 11, 115 using the tables of Weil (1952) Biometrics 8, 249
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 770 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
original value: 1.77 ml/kg; density: 0.967 g/cm3
Applicant's summary and conclusion
- Executive summary:
LD50 rabbit: 1712 mg/kg
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