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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: migrated dataset
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: special study and only one dose used, no dose-response relationship can be derived and thus no NOAEL or LOAEL can be deduced.

Data source

Reference
Title:
No information
Author:
Shelley WB (1974) p-Cresol: Cause of ink-induced hair depigmentation in mice. British Journal of Dermatology 90: 9-174

Materials and methods

Principles of method if other than guideline:
Method: other: see freetext RM
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: p-cresol, purity not noted

Test animals

Species:
mouse
Strain:
C57BL
Sex:
male
Details on test animals and environmental conditions:
migrated dataset

Administration / exposure

Details on exposure:
Route of Administration: dermal
Details on analytical verification of doses or concentrations:
migrated dataset
Duration of treatment / exposure:
6 weeks
Frequency of treatment:
3x/week
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 % in acetone
Basis:

No. of animals per sex per dose:
migrated dataset
Control animals:
other: no data specified
Details on study design:
Post-exposure period: 6 months
Positive control:
migrated dataset

Examinations

Observations and examinations performed and frequency:
migrated dataset
Sacrifice and pathology:
migrated dataset
Other examinations:
migrated dataset
Statistics:
migrated dataset

Results and discussion

Results of examinations

Details on results:
migrated dataset

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
< 0.5
Sex:
male
Dose descriptor:
LOAEL
Effect level:
<= 0.5
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Topical application caused depigmentation of the hair and pigmented epidermis, especially of the tail.  Large amounts of p-cresol were lethal and had a local caustic, 

erosive effect.

Applicant's summary and conclusion