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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
repeated dose toxicity: dermal
Remarks:
other: migrated dataset
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: special study and only one dose used, no dose-response relationship can be derived and thus no NOAEL or LOAEL can be deduced.

Data source

Reference
Title:
No information
Author:
Shelley WB (1974) p-Cresol: Cause of ink-induced hair depigmentation in mice. British Journal of Dermatology 90: 9-174

Materials and methods

Principles of method if other than guideline:
Method: other: see freetext RM
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
IUCLID4 Test substance: other TS: p-cresol, purity not noted

Test animals

Species:
mouse
Strain:
C57BL
Sex:
male
Details on test animals or test system and environmental conditions:
migrated dataset

Administration / exposure

Details on exposure:
Route of Administration: dermal
Details on analytical verification of doses or concentrations:
migrated dataset
Duration of treatment / exposure:
6 weeks
Frequency of treatment:
3x/week
Doses / concentrations
Remarks:
Doses / Concentrations:
0.5 % in acetone
Basis:

No. of animals per sex per dose:
migrated dataset
Control animals:
other: no data specified
Details on study design:
Post-exposure period: 6 months
Positive control:
migrated dataset

Examinations

Observations and examinations performed and frequency:
migrated dataset
Sacrifice and pathology:
migrated dataset
Other examinations:
migrated dataset
Statistics:
migrated dataset

Results and discussion

Results of examinations

Details on results:
migrated dataset

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
< 0.5
Sex:
male
Dose descriptor:
LOAEL
Effect level:
<= 0.5
Sex:
male

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Topical application caused depigmentation of the hair and pigmented epidermis, especially of the tail.  Large amounts of p-cresol were lethal and had a local caustic, 

erosive effect.

Applicant's summary and conclusion