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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Remarks:
other: migrated datset
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary literature: experimental details are missing, only one dose used

Data source

Reference
Title:
Inhalational effect of cresol isomers at low concentrations and means for improving detoxication processes in experiments on white rats.
Author:
Pereima VL
Year:
1975
Bibliographic source:
Dissertation, Lvov, pp. 86-90, cited in: IPCS (1995), Environmental Health Criteria Report No. 168 : Cresols, Inte

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: p-cresol, purity not noted

Test animals

Species:
rat
Strain:
not specified
Sex:
female
Details on test animals and environmental conditions:
migrated dataset

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
other: migrated dataset
Vehicle:
other: migrated dataset
Remarks on MMAD:
MMAD / GSD: migrated dataset
Details on inhalation exposure:
migrated dataset
Details on analytical verification of doses or concentrations:
migrated dataset
Duration of treatment / exposure:
4 months
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.01 mg/l
Basis:

No. of animals per sex per dose:
migrated dataset
Control animals:
other: no data specified
Details on study design:
Post-exposure period: 2 months
Positive control:
migrated dataset

Examinations

Observations and examinations performed and frequency:
migrated dataset
Sacrifice and pathology:
migrated dataset
Other examinations:
migrated dataset
Statistics:
migrated dataset

Results and discussion

Results of examinations

Details on results:
migrated dataset

Effect levels

Dose descriptor:
LOAEL
Effect level:
0.01 other: mg/l
Sex:
female

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

RS-Freetext:
Clinical signs of toxicity included loss of appetite, marked emaciation and decreased locomotor activity. Irritative effects, which persisted throughout recovery, were seen on
the nose, eye and skin.  Decreased body weight gain and lung weight, increased liver weight, oliguria and dystrophic changes in the lung and liver occurred. 

Throughout recovery the body weights remained depressed and urinary excretion remained low.

Applicant's summary and conclusion