Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-850-2 | CAS number: 7759-02-6
Brief exposure of recently ovulated mouse oocytes in M16 embryo culture medium supplemented with 1.6 mM SrCl2 for 2-10 min resulted in induction of a high incidence of parthenogenones. A lower incidence of activation and a significant rate of oocyte degeneration were observed when oocytes were incubated in M16 Sr2+ medium for 20-60 min. The majority of oocytes exposed to M16 Sr2+ for 2-10 min developed as single-pronuclear haploid parthenogenones (1PN). The incidence of this parthenogenetic class was reduced as the exposure time to M16 Sr2+ was increased from 2 to 30 min. Under these conditions a greater proportion of the activated oocytes developed as two-pronuclear diploid parthenogenones, due to the failure of second polar body extrusion. The activation frequency and the proportionate incidence of the pathways of parthenogenetic development following the exposure of ovulated oocytes to Ca-free M16 medium differed significantly from that induced by M16 Sr2+. Cytogenetic analysis of the single-pronuclear haploid class of Sr2+ induced parthenogenones at metaphase of the first-cleavage mitosis showed that this agent did not induce an increased incidence of chromosome segregation errors during the completion of the second meiotic division. Analysis of the developmental potential of the two-pronuclear class of diploid Sr2+ induced parthenogenones during the pre-implantation stages of embryogenesis revealed that their cell number and rate of cell division were less than those of fertilised embryos retained either in vivo or in vitro.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again