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Repeated dose toxicity: dermal

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Administrative data

short-term repeated dose toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
Justification for type of information:
In accordance with Annex VIII of REACH, Column 2, assessing the short-term repeated dose toxicity by the dermal route is relevant only if the inhalation of the substance is unlikely, which is not the case for the registered substance as the substance is a solid generating dust when handle. Moreover due to the particle size of the substance, it cannot be absorbed as such following a dermal exposure. It must first be dissolved for the absorption process to occur. However, the high lattice energy of the structure implies that it would require conditions far more extreme than those the substance will experience on the skin. Therefore no dissolution is expected following a dermal exposure, and no absorption will occur.

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion