Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Good documented study, although not GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-isopropylbenzonitrile
EC Number:
237-492-3
EC Name:
4-isopropylbenzonitrile
Cas Number:
13816-33-6
Molecular formula:
C10H11N
IUPAC Name:
4-(propan-2-yl)benzonitrile
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): cumin nitrile #80-34
- Lot/batch No.: #80-34

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
5.0 ; 3.12 ; 1.95 and 1.22 g/Kg
No. of animals per sex per dose:
10 males dosed at 5.0 g/Kg
10 males dosed at 3.12 g/Kg
10 males dosed at 1.95 g/Kg
10 males dosed at 1.22 g/Kg
Control animals:
no

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
3.9 other: g/Kg
Based on:
test mat.
95% CL:
> 3 - < 5.05

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information insufficient to be classified accroding GHS EU. Criteria used for interpretation of results: other: GHS EU
Conclusions:
The LD50 is 3.90 g/Kg of Body weight