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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: OECD Guideline Study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Ethane, 2-Chloro-1,1-Dimethoxy-
IUPAC Name:
Ethane, 2-Chloro-1,1-Dimethoxy-
Constituent 2
Reference substance name:
97-97-02
IUPAC Name:
97-97-02
Constituent 3
Chemical structure
Reference substance name:
2-chloro-1,1-dimethoxyethane
EC Number:
202-624-0
EC Name:
2-chloro-1,1-dimethoxyethane
Cas Number:
97-97-2
Molecular formula:
C4H9ClO2
IUPAC Name:
2-chloro-1,1-dimethoxyethane
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): Chloroacetaldehyde dimethylacetal
- Physical state: colourless liquid
- Solubility inw ater: 52g/L at 20°C
- Analytical purity: 98%

Test animals

Species:
rabbit
Strain:
Californian
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Schweizer Hof Untergröningen, Dr. Zimmermann
- Housing: individually in suspended stainless steel cages (2450 cm²)
- Diet: Raiffeisen Alleinfuttermittel 52/P for rabbits, once daily ca 180g
- Water: ad libitum
- Acclimation period: 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-22
- Humidity (%): 45-70
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
yes
Amount / concentration applied:
TEST MATERIAL: Amount applied: 0.5mL of the substance
VEHICLE: water
Duration of treatment / exposure:
4h
Observation period:
14d
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: back
- coverage: 6 cm²
- Type of wrap if used: no data, but warp was used

REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes, carefully
- Time after start of exposure: 4h

SCORING SYSTEM: mortality, toxic symptoms, general state of health, behaviour, body weight, skin results

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24h
Score:
0
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 14d
Score:
1
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: day 1-day 6
Score:
1
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: day 7
Score:
0
Reversibility:
fully reversible

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Under described test conditions following skin changes resulted from the test of chloroacetaldehyde dimethylacetal in albino-rabbits:
Erythema score: 1
Edema score: 0
Up from day 7 after substance application no changes were visible. Acute systemic toxic symptoms were not recognized.
The animals showed body weight gain during the observation period.
Executive summary:

Chloroacetaldehyde dimethylacetal was tested according to OECD Guideline 404 in 3 Albino Rabbits (Amount per animal: 0.5ml).

Under the test conditions skin changes resulted, assessed with max. 1 point erythema score. There was no edema score observed. Up from day 7 after substance application no changes were observed. Acute systemic toxic symptoms were not recognized.

The animals showed body weight gain during the observation period.