Dimethoxymethylvinylsilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

1984

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to a test protocol that is comparable to the appropriate OECD test guideline. The GLP status of the study is uncertain. Read-across is considered to be scientifically valid and reliability 2.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Remarks:

Although a statement regarding GLP was not available with the study report, it is known that this laboratory conducted studies in compliance with GLP at this time.

Test type:

other: LD50

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trimethoxyvinylsilane

EC Number:

220-449-8

EC Name:

Trimethoxyvinylsilane

Cas Number:

2768-02-7

IUPAC Name:

trimethoxy(vinyl)silane

Test animals

Species:

rat

Strain:

other: Hilltop Wistar albino

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: 200- 300g

Administration / exposure

Route of administration:

other: intubation

Vehicle:

other: none

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: not reported

Doses:

16.0, 8.0, 4.0, 2.0 and 1.0 ml/kg bw in males; 16.0, 8.0, 4.0 and 2.0 ml/kg bw in females

No. of animals per sex per dose:

45

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: Body weights were recorded on days 0, (before dosing), 7 and 14 (prior to termination).

- Necropsy of survivors performed: yes.

- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: At necropsy, each animal was subjected to gross pathologic evaluation.

Statistics:

LD50 with 95% confidence limits; males 7.34 (4.61 to 11.7) ml/kg; females 7.46 (5.16 to 10.8) ml/kg. LD50 slopes; males 3.67, females 4.22.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

7.34 - 7.46 mL/kg bw

Remarks on result:

other: Equivalent to 7120 and 7236 mg/kg bw based on relative density of 0.97 g/cm3

Mortality:

Deaths occurred at 2.5 hours to 4 days.

Clinical signs:

other: Sluggishness, red to brown discharge (around nose, eyes and anus), lacrimation, piloerection, unkempt appearance, prostration, emaciation and unsteady gait were amongst the signs of toxicity observed. Survivors recovered at one to 5 days. With the excepti

Gross pathology:

At necropsy, there were several instances of dark red kidney section among victims.

Any other information on results incl. tables

 Table 1: Number of animals dead and time range within which mortality occurred.

 

Dose (ml/kg)	Mortality (# dead/total)			Time range of deaths (days)
	Male	Female	Combined
16	5/5	5/5	10/10	0 and 1
8	3/5	3/5	6/10	1,2,3,4
4	0/5	0/5	0/10
2	1/5	0/5	1/10	3
1	0/5	0/5	0/10

 

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

LD50 values of 7.34 ml/kg in males and 7.46 ml/kg in females were determined in a reliable study conducted according to a protocol that was comparable to OECD 401. The GLP status of the study is uncertain.