Registration Dossier
Registration Dossier
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EC number: 403-240-8 | CAS number: 106264-79-3 DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- EPA 560/6-83-001
- GLP compliance:
- yes
Test material
- Reference substance name:
- A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
- EC Number:
- 403-240-8
- EC Name:
- A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
- Cas Number:
- 106264-79-3
- Molecular formula:
- C9H14N2S2
- IUPAC Name:
- reaction mass of: 3,5-dimethylthio-2,4-toluenediamine 3,5-dimethylthio-2,6-toluenediamine
- Test material form:
- other: clear liquid
- Details on test material:
- purity: 95.14 % diamines
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: neat
- Controls:
- not specified
- Amount / concentration applied:
- 600 mg
- Duration of treatment / exposure:
- 4 h
- Number of animals:
- 6 (3 male, 3 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0
- Irritation parameter:
- edema score
- Basis:
- mean
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Max. duration: d; Max. value at end of observation period: 0
- Other effects:
- No irritant response was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance was found to be non-irritating to rabbit skin.
- Executive summary:
The study was performed according to OECD guideline no. 404 and EU method B.4. 0.5 ml test item was applied to one intact skin site for 4 hrs on each 6 rabbits (3M,3F). No signs of irritancy (oedema or erythema) were seen in any of the animals. Scores were all 0. The study ended after 72 hours. In conclusion, the substance was found to be non-irritating to rabbit skin.
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