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EC number: 403-240-8 | CAS number: 106264-79-3 DM-C-TDA; DMTDA; ETHACURE (R) 300 CURATIVE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant guideline study
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- EEC B.1, EPA 560/6-83-001
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
- EC Number:
- 403-240-8
- EC Name:
- A mixture of: 3,5-dimethylthio-2,4-toluenediamine; 3,5-dimethylthio-2,6-toluenediamine
- Cas Number:
- 106264-79-3
- Molecular formula:
- C9H14N2S2
- IUPAC Name:
- reaction mass of: 3,5-dimethylthio-2,4-toluenediamine 3,5-dimethylthio-2,6-toluenediamine
- Test material form:
- other: clear liquid
- Details on test material:
- purity: 95.14 % diamines
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- - Range-finding test: 500, 3200 and 5000 mg/kg
- Main study: 1000, 1250, 1600 and 2500 mg/kg - No. of animals per sex per dose:
- - Range finding test: 3 groups of 2 animals (1 M, 1 F)
- Main study: 4 groups of 10 fasted rats (5M, 5F) - Control animals:
- no
Results and discussion
- Preliminary study:
- A dose range finding study was performed using 3 groups of 2 animals (1 M, 1 F). Animals were administered test compound at 500, 3200 and 5000 mg/kg by oral gavage. None of the rats died at 500 mg/kg. All of the rats died at the other two dose groups. In the definitive study, 4 groups of 10 fasted rats (5M, 5F) were orally administered the test article at 1000, 1250, 1600 and 2500 mg/kg.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 515 mg/kg bw
- 95% CL:
- >= 960 - <= 2 048
- Mortality:
- Male: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1250 mg/kg bw; Number of animals: 5; Number of deaths: 0
Male: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 4
Male: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 4
Female: 1000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 1250 mg/kg bw; Number of animals: 5; Number of deaths: 2
Female: 1600 mg/kg bw; Number of animals: 5; Number of deaths: 3
Female: 2500 mg/kg bw; Number of animals: 5; Number of deaths: 5 - Clinical signs:
- other: Signs of toxicity related to dose levels: A dose range finding study was performed using 3 groups of 2 animals (1M, 1F). Animals were administered test compound at 500, 3200 and 5000 mg/kg by oral gavage. None of the rats died at 500 mg/kg. All of the ra
- Gross pathology:
- Effects on organs:
a) 1000, 1250 and 1600 dose levels
Necropsy of animals dying in study revealed hemorrhagic stomach lesions, discolored lungs, hydrothorax, discolored fluid-filled bladders
b) 2500 mg/kg dose level
No visible lesions observed in any animal at terminal necropsy
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity LD50 was found to be 1515 mg/kg bw for males/females. In conclusion, the test substance has to be classified Toxicity Category IV based on the results of this test.
- Executive summary:
The acute oral toxicity on rats was determined in a GLP study according to OECD guideline 401 and EU test method B.1. Vehicle was corn oil. A dose range finding study was performed using 3 groups of 2 animals (1 M, 1 F). Animals were administered test compound at 500, 3200 and 5000 mg/kg by oral gavage. None of the rats died at 500 mg/kg. All of the rats died at the other two dose groups. In the definitive study, 4 groups of 10 fasted rats (5M, 5F) were orally administered the test article at 1000, 1250, 1600 and 2500 mg/kg.
Signs observed were decreased activity, ptosis, piloerection, decreased muscle tone, abnormal gait, abnormal stance, poor grooming, diarrhea, chromodacryorrhea and prostration. One of 10 died at 1000 mg/kg, 2110 at 1250 mg/kg, 7110 at 1600 mg/kg and 9/10 at 2500 mg/kg. Necropsy of dead animals revealed hemorrhagic lesions in the stomach, discolored intestines, discolored lungs, hydrothorax and discolored fluid filled bladders.
The acute oral toxicity LD50 was found to be 1515 mg/kg bw for males/females. In conclusion, the test substance has to be classified Toxicity Category IV based on the results of this test.
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