Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: scientific review
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Peer reviewed data from the EU Risk Assessment Report for TCPP .

Data source

Reference
Reference Type:
publication
Title:
EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7,
Author:
EC
Year:
2008
Bibliographic source:
EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7, European Communities, May 2008

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: no data
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Dermal absorption:

The EU RAR adopts the worst case mean total dermal absorption value of 40 % for assessment of risks where skin exposure to TCPP is likely.

 

Oral absorption:

The EU RAR adopts the worst case mean total oral absorption value of 80 % for assessment of risks where oral exposure to TCPP is likely.

 

Inhalation absorption:

The EU RAR adopts the worst case mean total inhalation absorption value of 100 % for assessment of risks where inhalation exposure to TCPP is likely

 

Metabolism:

TCPP is rapidly metabolised (approx 98%) with main metabolites being 0,0-[Bis(1-chloro-2-propyl)]-0-(2-propionic acid)phosphate, bis(1- chloro-2-propyl)monophosphoric acid and 1-chloro-2-propanol.

Applicant's summary and conclusion