Tris(2-chloro-1-methylethyl) phosphate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: scientific review

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Peer reviewed data from the EU Risk Assessment Report for TCPP .

Data source

Reference

Reference Type:

publication

Title:

EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7,

Author:

EC

Year:

2008

Bibliographic source:

EU RAR (2008) European Union Risk Assessment Report TRIS(2-CHLORO-1-METHYLETHYL) PHOSPHATE (TCPP) CAS No: 13674-84-5, EINECS No: 237-158-7, European Communities, May 2008

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: no data

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Tris(2-chloro-1-methylethyl) phosphate

EC Number:

237-158-7

EC Name:

Tris(2-chloro-1-methylethyl) phosphate

Cas Number:

13674-84-5

Molecular formula:

C9H18Cl3O4P

IUPAC Name:

tris(2-chloro-1-methylethyl) phosphate

Results and discussion

Any other information on results incl. tables

Dermal absorption:

The EU RAR adopts the worst case mean total dermal absorption value of 40 % for assessment of risks where skin exposure to TCPP is likely.

 

Oral absorption:

The EU RAR adopts the worst case mean total oral absorption value of 80 % for assessment of risks where oral exposure to TCPP is likely.

 

Inhalation absorption:

The EU RAR adopts the worst case mean total inhalation absorption value of 100 % for assessment of risks where inhalation exposure to TCPP is likely

 

Metabolism:

TCPP is rapidly metabolised (approx 98%) with main metabolites being 0,0-[Bis(1-chloro-2-propyl)]-0-(2-propionic acid)phosphate, bis(1- chloro-2-propyl)monophosphoric acid and 1-chloro-2-propanol.