Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Skin sensitisation assessment:

There is one reliable study available for this endpoint.

The sensitization of the test article, 1,6 Divinylperfluorohexane, was assessed in guinea-pig using OECD Guidelines 406 (Buehler test). The body weight gain in the animals throughout the test was normal. Twenty-four hours after 6h patch application of each inductive phase (3 exposures), no signs of skin irritation were observed in the animals treated with the test article. At challenge, no animal treated with the test article concentration applied undiluted showed positive reaction. No skin reactivity was observed in the negative control group. On the basis of this result, under the experimental conditions applied, 1,6 Divinylperfluorohexane did not appear to possess sensitizing properties.

Migrated from Short description of key information:
OECD 406 guideline study with guinea pig (not sensitizing)

Justification for selection of skin sensitisation endpoint:
Study performed according to OECD TG 406 and EC method B.6.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

No study available, and no specific alert or observation reported for the substance.

Justification for classification or non-classification

The test material appears to have no skin sensitising effect in an in vivo study with guinea pigs. Therefore, 1,6 Divinylperfluorohexane does require classification for skin sensitisation according to the criteria of the DSD or the CLP regulation EC No. 1272/2008.