Registration Dossier

Administrative data

Description of key information

- Acute Dermal Irritation/Corrosion (OECD TG 404): no skin irritation for rabbit
- Acute Eye Irritation/Corrosion (OECD TG 405): no eye irritation for rabbit
- There was no evidence of respiratory irritation reported in the acute inhalation toxicity in rats.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Skin and eye corrosion/irritation assessment:

For each irritation/corrosion endpoint, a reliable study is available:

Skin corrosion/irritation:

In an acute dermal irritation study, young adult New Zealand white rabbits (3 animals) were dermally exposed to 0.5 mL of the test article 1,6 Divinylperfluorohexane for 3 minutes, 1 hour and 4 hours. Test material was applied uniformly by gentle inunction onto the cleared dorsal area of the trunk of the animals. The test site was observed immediately after the 3 minute and the 1 hour- exposure period and at 72 hours in the first rabbit, and at 1, 24, 48 and 72 hours after the 4 -hour exposure period (all rabbit). No animals died. No clinical signs or behavioral alterations were noted. At the application sites, no signs of dermal irritancy were noted in any rabbit. The test article, when administered by dermal route to rabbits under the experimental conditions adopted, is to be considered "non irritant" for the skin.

Eye corrosion/irritation:

In an acute eye irritation study, young adult New Zealand white rabbits (3 animals) were administered 0.1 ml of the test article 1,6 Divinylperfluorohexane in the conjunctival sac of the right eye. The eye was observed at 1, 24, 48 and 72 hours after the test application. No animals died. No clinical signs or behavioral alterations were noted. No modification of cornea, iris and conjunctivae was observed in any animal. The test article, when administered by ocular route to rabbits under the experimental conditions adopted, is to be considered "non irritant" for the eye.

Therefore, based on available in vivo studies with rabbits, the test substance is not classified for skin and eye irritation according to DSD and CLP regulation.


Justification for selection of skin irritation / corrosion endpoint:
Study performed according to OECD TG 404 and EC method B.4.

Justification for selection of eye irritation endpoint:
Study performed according to OECD TG 405 and EC method B.5.

Justification for classification or non-classification

The test material appears to have no skin or eye irritant effect in in vivo studies with rabbits. Therefore, 1,6 Divinylperfluorohexane does require classification for skin and eye irritation according to the criteria of the DSD or the CLP regulation EC No. 1272/2008.