Registration Dossier
Registration Dossier
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EC number: 227-458-6 | CAS number: 5850-86-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: no data
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Sodium 4-(2-hydroxynaphth-1-ylazo)-3-methylbenzenesulphonate
- EC Number:
- 227-458-6
- EC Name:
- Sodium 4-(2-hydroxynaphth-1-ylazo)-3-methylbenzenesulphonate
- Cas Number:
- 5850-86-2
- Molecular formula:
- C17H14N2O4S.Na
- IUPAC Name:
- sodium 4-(2-hydroxynaphth-1-ylazo)-3-methylbenzenesulphonate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on dermal exposure:
- 50% suspension in a 0.5% aqueous carboxymethyl cellulose preparation
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: No abnormalities
- Gross pathology:
- No abnormalities
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The tested item was found to be non-toxic for dermal exposure with a LD50 > 2500 mg/kg bw.
- Executive summary:
The acute dermal toxicity of the tested substance in rats was assessed with this test and the LD50 value was > 2500 mg/kg.
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