Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
other: References
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well known and documented metabolism

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Conclusions:
-
Executive summary:

In the small intestine, Pyridoxine Hydrochloride is readily absorbed. A bioavailability of about 75% is reported, irrespective the consumption with or without food. The absorbed vitamin B6 is rapidly converted by pyridoxal kinase and ATP in the tissues (mainly liver, brain, and kidney) into the co-enzymes pyridoxal-phosphate and, to a lesser extent pyridoxamine-phosphate, which are distributed throughout the tissues. Pyridoxal is converted in the liver by aldehyde oxidase to 4-pyridoxic acid, which is excreted in the urine together with small amounts of pyridoxol, pyridoxal and pyridoxamine.

 

No data are available on dermal or inhalation bioavailability. Dermal bioavailability of B6 can be estimated to be 80% based on the Potts & Guy model and Kroes et al. (Potts & Guy 1992, Kroes et al. 2007).

 

 

References:

EVM (2003) Expert Group on Vitamins and Minerals, Safe Upper Levels for Vitamins and Minerals: Vitamin B6 (Pyridoxine). https://cot.food.gov.uk/sites/default/files/vitmin2003.pdf

 

Kroes et al. (2007) Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients. Food Chem Toxicol 45: 2533-2562

 

IOM (1998) Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline; A Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline and Subcommittee on Upper Reference Levels of Nutrients, Food and Nutrition Board, Institute of Medicine; National Academies Press (US)

 

Potts & Guy (1992) Predicting Skin Permeability. Pharma Res. 9(5): 663-669