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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
Not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, non-guideline, published in peer reviewed literature, limitations in design and/or reporting but otherwise adequate for assessment
Cross-reference
Reason / purpose:
reference to other study

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1969

Materials and methods

Principles of method if other than guideline:
Single dermal application followed by 14 days observation.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS
Weight at study initiation: 2.5-3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
Technique used based on the one-day cuff method of Draize and associates. Fur removed from entire trunk by clipping and dose retained beneath an impervious plastic film. Animals immobilised during the 24 hour application period after which film is removed.
Duration of exposure:
24 hours
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days
Statistics:
Dermal LD50 (and its fiducial range) estimated by the method of Thompson (Thompson WR, 1947) using the Tables of Weil (Weil CS, 1952)

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
1 183 mg/kg bw
Remarks on result:
other: (1.59 ml/kg bw)
Sex:
male
Dose descriptor:
LD50
Effect level:
1.59 mL/kg bw
95% CL:
0.97 - 2.59

Applicant's summary and conclusion

Conclusions:
The acute dermal LD50 of cyclopentene to male rabbits was 1.59 mL/kg (0.97-2.59). Assuming a density of 0.744g/ml, Rabbit Dermal LD50 = 1183mg/kg.
Executive summary:

In a range-finding acute dermal toxicity study,using the same experimental methods as described in an earlier publication (Smyth et al, 1962), the acute dermal LD50 of cyclopentene to male rabbits was 1.59 mL/kg (0.97-2.59). Assuming a density of 0.744g/ml, Rabbit Dermal LD50 = 1183mg/kg