Registration Dossier
Registration Dossier
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EC number: 202-869-3 | CAS number: 100-60-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1951
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: only orientating information about the inhalation hazard to vapours.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
- Principles of method if other than guideline:
- 8h exposure of rats to vapour generated by blowing air through the liquid test substance. Animals observed up to 8 days.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
- Limit test:
- no
Test material
- Details on test material:
- Name of the test substance used in the study report: N-Monomethylcyclohexylamin
physical state: liquid
other identifier: structural formula
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- air
- Details on inhalation exposure:
- Temperature 22.5°C
Atmosphere generated by blowing air through column containing a layer of 2 cm of the test substance.
Airflow 200L/h - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Remarks on duration:
- 30 min, 2 h, 8 h
- Concentrations:
- 22.8 mg/l
- No. of animals per sex per dose:
- 30 min: 6 animals
2 h: 6 animals
8 h: 12 animals
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 22.8 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other: Mortality 5/12 animals
- Mortality:
- 30 min: None of 6 animals
2 h: 2 of 6 animals
8 h: 5 of 12 animals - Clinical signs:
- other: rhinorrhoea, irregular and laboured breathing, trembling. Surviving animals were free of clincial signs within 2 days.
- Gross pathology:
- Nothing abnormal detected at terminal sacrifice after 8 days
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Exposure to vapours at a concentration of 22.8 mg/L (vapour) caused mortality in 5 of 12 tested rats.
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