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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

NOEC (3 h): ≥ 1000 mg/L for the respiration of activated sludge microorganisms (OECD 209), read across

Key value for chemical safety assessment

Additional information

Since no experimental studies investigating the toxicity of 1,3-Propanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4) to aquatic microorganisms are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substances Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) and 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID Section 13.

The first study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) was performed according to OECD Guideline 209 and GLP (Roulstone, 2012).Activated sludge of a predominantly domestic sewage was exposed to the test substance during 3 hours. No effect on the respiration of activated sludge was observed, and the NOEC (3 h) was reported to be ≥ 1000 mg/L.

The second study conducted with 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was performed according to OECD Guideline 209 and GLP (Mead, 1999). Activated sludge of a predominantly domestic sewage was exposed to the test substance during 3 hours. No effect on the respiration of activated sludge was observed, and the NOEC (3 h) was reported to be ≥ 1000 mg/L.

Based on the available results from these structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that 1,3-Propoanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4) will not exhibit toxic effects on aquatic microorganisms up to the limit of water solubility.