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Short-term toxicity to fish

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Description of key information

No effects up to the limit of water solubility (OECD 203), read across

Key value for chemical safety assessment

Additional information

Since no experimental studies investigating the short-term toxicity of 1,3-Propnediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4) to fish are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substances Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) and 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID Section 13.

The first study with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) was performed, according to OECD Guideline 203 and GLP, in a semi-static system, using Oncorhynchus mykiss as test organism (Parr, 2012). During 96 h, the fish were exposed to the nominal test concentrations of 100% v/v, corresponding to a measured concentration of 0.086 mg/L. This was the highest attainable concentration, due to the poor solubility of the test substance. The test solutions were prepared using a solvent, and undissolved test material was removed by filtration. No mortality occurred during the study, and the LC50 (96 h) was reported to be > 0.086 mg/L.

Similarly, the second study 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) was performed, according to OECD Guideline 203 and GLP, in a semi-static system, using the same species as test organism (Wetton & Mullee, 1999). During 96 h, the fish were exposed to a loading test concentration of 100 mg/L, corresponding to a measured concentration of < 0.02 mg/L (below LOQ). The test solutions were prepared using a solvent, and undissolved test material was removed by filtration. No mortality occurred during the study, and the LL50 (96 h) was reported to be > 100 mg/L (nominal).

Based on the available results from these structurally related read-across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that of 1,3-Propanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4) will not exhibit short-term effects on fish up to the limit of water solubility.