Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

There are no data available investigating the aquatic toxicity of 1,3-Propanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4). In order to fulfil the standard information requirements, in accordance with Annex XI, 1.5, of Regulation (EC) No 1907/2006, read-across from structurally related substances was conducted.

In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met.” In particular for aquatic toxicity, information shall be generated whenever possible by means other than vertebrate animal tests, which includes the use of information from structurally related substances (grouping or read-across).

Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006 whereby substances may be predicted as similar provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity, Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS 68855-18-5) and 3,5,5-trimethylhexanoic acid mixed tetraesters with PE and valeric acid (CAS 131459-39-7) are used as source substances. 

The above mentioned substances are considered to be similar on the basis of the structural similar properties and/or activities. The available endpoint information on acute/chronic aquatic toxicity of the source substances is used to predict the same endpoints for 1,3-Propoanediol, 2,2-dimethyl-, C5-9 carboxylates (CAS 85711-80-4). The target and source substances are all neopentyl glycole (NPG), or pentaerythritol (PE) and two or four carboxylic fatty acid substituents. The alcohol moieties of target and source substances share a neopentane backbone as basis. The fatty acid moieties comprise a chain length of C7 to C9 branched.

The ester group is the common functional group in all members of the analogue approach and no other functional groups are present in the molecules. A detailed analogue approach justification is provided in the technical dossier (see IUCLID Section 13).

All available experimental data on the source substances performed according to internationally accepted guidelines indicate no evidence of acute and chronic toxicity to aquatic organisms. Data for all three trophic levels are available. No toxicity was observed up to the limit of water solubility in all available experimental studies.

The degradation process in commercial sewage treatment plants is not suspected to be inhibited by the target substance. Available studies for both source substances performed with activated sludge from sewage treatment plants do not indicate a risk since respiration of activated sludge microorganisms was not inhibited.