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EC number: 440-550-2 | CAS number: 244021-01-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to OECD-Guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- Identity: TKA 40270 (CGPS 345)
Batch no.: Lot 02243FC7, Op. 1/07
Purity: Confidential Information (see Analytical Certificate No. 38291-1)
Expiration date: 01-Oct-2012
Solubility in water: <0.21 mg/L
Aggregate state / physical form at room temperature: Liquid
Color: Colorless to yellow
Storage conditions: Storage at under 18 °C may lead to partial solidification. To reliquify, heat contents to 25-35 °C.Protect from light. (At RCC: At room temperature at about 20 °C, away from direct sunlight.)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Undiluted filtrate and dilutions 1:2.2, 1:4.6, 1:10 and 1:22 + control
- Sampling method: The determination of the actual test item concentrations, duplicate samples were taken from each treatment before the start of the test and at the end of the test after 48 hours.
- Sample storage conditions before analysis: The samples were analyzed immediately after sampling
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Due to the low water solubility of the test item, a dispersion of the test item with the loading rate
of 100 mg/L was continuously stirred at room temperature in the dark over 96 hours. Then, the
dispersion was filtered. The undiluted filtrate and the dilutions 1:2.2, 1:4.6, 1:10 and 1:22 were
used as test media. Additionally, a control was tested in parallel. The test method was based on
the "OECD Guidance Document on Aquatic Toxicity Testing of Difficult Substances and
Mixtures, 2000."
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Dahpnia magna Straus
- Source: The clone has been bred in the RCC laboratories in reconstituted water
Study design
- Test type:
- static
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- 6-24 h
Test conditions
- Hardness:
- 250 mg/L as CaCO3
- Test temperature:
- 20°C
- pH:
- 7.9 to 8.1
- Dissolved oxygen:
- 8.0 mg/L
- Nominal and measured concentrations:
- At the start of the test the measured concentrations of the test item in the test media of dilutions
1:4.6 and 1:2.2 and of the undiluted filtrate amounted to 0.08, 0.12 and 0.31 mg/L, respectively.
At the end of the test, the measured concentrations in these test media were below the LOQ
(limit of quantification), 0.11 and 0.26 mg/L, respectively. No test item could be detected in the
test media of the two lowest test concentrations (dilutions 1:22 and 1:10). - Details on test conditions:
- The water temperature was maintained at 20 °C.
The test was performed in the dark to avoid a photolytic degradation of the test item.
The daphnids were not fed during the test. - Reference substance (positive control):
- yes
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: loading rate of test material
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: loading rate of test material
- Basis for effect:
- mobility
- Details on results:
- -No remarkable observations were made concerning the appearance of the test media. All test media were clear solutions throughout the entire test duration.
-The 48-hour EC50 of the test item could not be calculated because none of the responses exceeded 50%. The 48-hour EC0 and the 48-hour NOEC
(highest concentration tested without toxic effects after 48 hours) of TKA 40270 (CGPS 345) were both at a dilution of 1:1.22, corresponding to a
measured concentration of 0.12 mg/L. - Results with reference substance (positive control):
- For evaluation of the quality of the daphnia clone and the experimental conditions, potassium
dichromate is tested as a positive control twice a year. The result of the latest positive control test
in November 2007 (48-hour EC50: 0.53 mg/L, RCC Study No. B69794) indicated that the
sensitivity of the test organisms was within the historical range of the RCC laboratory (48-hour
ECSO from 1996 to 2007: 0.53-1.1 mg/L).
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- No remarkable observations, clear test medium
The 48-hour EC0 and the 48-hour NOEC of TKA 40270 (CGPS 345) are without toxic and no significant immboilization was observed. - Executive summary:
The 48-hour EC50 of the test item could not be calculated because none of the responses exceeded 50%. The 48-hour EC0 and the 48-hour NOEC (highest concentration tested without toxic effects after 48 hours) of TKA 40270 (CGPS 345) were both 0.12 mg/L (dilution 1:2.2), since no significant immobilization was observed up to and including this test concentration. The EC100 could not be determined due to the low toxicity of the test item up to the test item concentration of 0.28 mg/L (undiluted filtrate, loading rate of 100 mg/L), representing the highest test item concentration which could be dissolved in the test water.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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