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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From December 1, 2014 to January 30, 2015
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
GLP compliance:
not specified
Type of method:
flask method
Key result
Water solubility:
9.999 g/L
Temp.:
20 °C
pH:
6.4

Following solubilities were determined at different incubation times at 20°C:

Incubation time (h)

Water solubility [g/L]

Average[g/L]

24

9.802

9.999

48

10.018

72

10.178

 

Conclusions:
The water solubility of the test substance at 20°C was determined to be 9.999 g/L.
Executive summary:

A study was conducted to determine the water solubility of the test substance, according to EU Method A.6. About 1.0 g of the test substance was suspended in 100 mL deionised water and stirred in a heated water bath at 30°C for 24, 48, and 72 h, respectively. After incubation, the sample suspensions were cooled to 20°C and kept at this temperature for 24 h without stirring. Afterwards, the samples were centrifuged (3,000 U/min) at 20°C for 15 mins and a second time at 4,000 U/min for 2 h. The still cloudy water phases were filtrated and then analysed by liquid chromatography. Under the study conditions, water solubility of the test substance at a temperature of 20°C was determined to be 9.999 g/L (Seiler, 2015).

Description of key information

The water solubility was determined using flask method, according to EU Method A.6 (Seiler, 2015).

Key value for chemical safety assessment

Water solubility:
9.999 g/L
at the temperature of:
20 °C

Additional information