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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From November 24, 2014 to February 11, 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: OECD 105
Deviations:
no
Qualifier:
according to
Guideline:
other: EU Method A.6
Deviations:
no
GLP compliance:
not specified
Key result
Medium:
n-octanol
Solubility:
96.61 g/L
Temp.:
20 °C

Results: The concentrations of the different test solutions were calculated automatically using the equation of the calibration curve. The results are summarised in the table below:

Incubation time (h) Individual results (mg/mL) Average (mg/mL)
24 2.868/2.880 2.868
48 2.859/2.832 2.845
72 2.862/2.837 2.85

The analytical results allow the calculation of the n-octanol solubility of the test substance.

Incubation time (h) n-octanol solubility (g/L) Average (g/L)
24 96.74 96.61± 0.420
48 96.14
72 96.95

N-octanol solubility of the test substance is 96.61 g/L±0.420 g/L.

N-octanol solubility was determined at 20oC.

Conclusions:
Under the study conditions, the n-octanol solubility of the test substance was determined to be 96.61 g/L of solution at 20.0 ± 0.5°C.
Executive summary:

A study was conducted to determine the n-octanol solubility of the test substance according to OECD Guideline 105 and EU Method A.6. Under the study conditions, the n-octanol solubility of the test substance was determined to be 96.61 g/L of solution at 20.0 ± 0.5°C (Schwarzkopf, 2015).

Description of key information

The n-octanol solubility was determined according to OECD Guideline 105 (Schwarzkopf, 2015).

Key value for chemical safety assessment

At the temperature of:
20 °C
Solubility in organic solvents at 20°C:
96.61 g/L

Additional information