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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 210-519-6 | CAS number: 617-52-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary source available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Growth-retarding activity and chemical structure of certain derivatives of itaconic acid
- Author:
- Karanov EN, Vasilev GN, Hristova LN
- Year:
- 1 975
- Bibliographic source:
- Doklady Bolgarskoi Akademii Nauk 28(8):1085-8
Materials and methods
- Limit test:
- no
Test material
- Reference substance name:
- Itaconic acid, Monomethyl ester of itaconic acid, Monoethyl ester of itaconic acid and Diethyl ester of itaconic acid
- IUPAC Name:
- Itaconic acid, Monomethyl ester of itaconic acid, Monoethyl ester of itaconic acid and Diethyl ester of itaconic acid
- Details on test material:
- - Name of test material (as cited in study report):
Itaconic acid
Monomethyl ester of itaconic acid
Monoethyl ester of itaconic acid
Diethyl ester of itaconic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Agness Blum albino mice
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Details on exposure:
- no data
- Doses:
- not reported
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 600 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: The value is an estimation based on comparable values for Itaconic acid, Monomethyl ester of itaconic acid, Monoethyl ester of itaconic acid and Diethyl ester of itaconic acid, which were all between 500 and 600 mg/kg bw (see Table 1).
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
- Table 1: Acute toxicity of derivatives of itaconic acid
Substance |
LD 50 (mouse) in mg/kg bw after ip injection |
Itaconic acid |
500 |
Monomethyl ester of itaconic acid |
500 |
Monoethyl ester of itaconic acid |
500 |
Diethyl ester of itaconic acid |
600 |
Applicant's summary and conclusion
- Conclusions:
- The acute toxicity of dimethyl itaconate after ip injection in mice is approximated based on a read across from several derivatives of itaconic acid. The LD 50 (mouse) after ip injection is ca. 500 mg/kg bw.
- Executive summary:
The autors of a secondary source publication shortly report the acute toxicity of different derivatives of itaconic acid (Itaconic acid, Monomethyl ester of itaconic acid, Monoethyl ester of itaconic acid and Diethyl ester of itaconic acid) after ip injection in Agness Blum albino mice.
As all these substances have a comparable acute toxicity and are structurally closely related to dimethyl itaconate (DMI), the acute toxicity of DMI in mice after ip injection can be approximated based on a read across from several derivatives of itaconic acid. The LD 50 (mouse) after ip injection is ca. 500 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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