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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Description of key information

ErC50 (72h) = 37 mg/L, NOEC (72h) = 2.1 mg/L for Pseudokirchneriella subcapitata (OECD 201, full test), read-across

Key value for chemical safety assessment

EC50/LC50 for freshwater algae:
37 mg/L
EC10, LC10 or NOEC for freshwater algae:
2.1 mg/L

Additional information

No studies investigating the toxicity of sodium ethylparaben (CAS No. 35285 -68 -8) to algae are available. Therefore, toxicity data of the corresponding acid ethylparaben (CAS No. 120 -47 -8) are used as read across.

This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have identical chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.

For the toxicity of the analogue read across substance ethylparaben the following data are available:

The toxicity to algae was investigated in a GLP study under static conditions according to OECD 201 with Pseudokirchneriella subcapitata (Kimmel, 2012). Algae were exposed to nominal concentrations of 2.1, 4.6, 10, 21 and 46 mg/L. The test item was stable in the test media over the test period. The study resulted in an ErC50 of 37 mg/L and a NOEC of 2.1 mg/L. Additional data on the toxicity to algae are presented in the dossier “Environmental and Health Assessment of Substances in Household Detergents and Cosmetic Detergent Products” by the Danish Ministry of Environment and Energy (Madsen et al., 2001). Herein, results from a study according to ISO 8692 are cited. Algae were exposed to concentrations of 1, 2, 5, 10, 20, 50 and 100 mg/L. The EC50 was determined to be 18 mg/L. The NOEC was determined to be 5 mg/L.