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Diss Factsheets
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EC number: 700-421-6 | CAS number: 1215122-81-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- From 8.2.1988 to 30.3.1988
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- There are no deviations from the recommended guideline. In accordance to the ECHA guidance document "Practical guide 6: How to report read-across and categories (March 2010)", the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance. It is hypothesized that the toxicity of the target chemical can be derived from the respective toxicity data of DMAs with comparable length of alkyl chain (source substances). The underlying scientific rationale is based on the physico-chemical property of the target chemical and “chain length category”.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Dodecyldimethylamine
- EC Number:
- 203-943-8
- EC Name:
- Dodecyldimethylamine
- Cas Number:
- 112-18-5
- IUPAC Name:
- N,N-dimethyldodecan-1-amine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: Male: 194g Female: 173g
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 50 +/-20
- Air changes (per hr): 16
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Male: 1250 / 1600 and 2000 mg/kg
Female: 1250 / 1600 and 1800 mg/kg - No. of animals per sex per dose:
- 7 Females and 8 Males
- Control animals:
- no
- Statistics:
- probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 890 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 750 - 2 560
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 450 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 110 - 1 720
- Mortality:
- Mortality was observed by day 1 or 2 after gavage.
- Clinical signs:
- other: Animals showed besides from unspecific poisoning symptoms an influenced movement of body and breathing, bloody crusted eye lids and mouths, narrowed eye lid splits and diarrhoea.
- Gross pathology:
- Symptoms were reversible in male after 5 and female animals after 9 days after gavage.
Any other information on results incl. tables
Dosis in mg/kg Kgw. | Concentration in % (w/v) | Appication Volume in ml/kg Kgw. | Nº Male | Nº Female |
1250 | 12.5 | 10 | 5 | 5 |
1600 | 16.0 | 10 | 5 | 5 |
1800 | 18.0 | 10 | - | 5 |
2000 | 20.0 | 10 | 5 | - |
Dosis mg/kg Kgw. | Lethality | |||
Male absolute | Male relativ (%) | Female absolut | Female relativ (%) | |
1250 | 0/5 | 0 | 1/5 | 20 |
1600 | 1/5 | 20 | 3/5 | 60 |
1800 | - | - | 5/5 | 100 |
2000 | 3/5 | 60 | - | - |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral toxicity of the target substance was assessed based on the analogue appraoch using N,N-dimethyldodecan-1-amine as read-across supporting substance. Under the conditions of this study the LD50 of N,N-dimethyldodecan-1-amine was 1450 mg/kg for female rats and 1890 mg/kg for male rats
- Executive summary:
The acute oral toxicity of the target substance was assessed based on the analogue appraoch using N,N-dimethyldodecan-1-amine as read-across supporting substance.
The testing of acute toxicity of the substance in the Wistar rat gave the following dosage LD50:
Female animals: 1450 mg/kg body weight; Male animals: 1890 mg/kg body weight
Mortality was observed within 2 days after gavage.
Animals showed besides from unspecific poisoning symptoms an influenced movement of body and breathing, bloody crusted eye lids and mouths, narrowed eye lid splits and diarrhoea. Symptoms were reversible in male after 5 and female animals after 9 days after gavage.
The development of body weight was in the first testing week in one female animal with 1250 mg/kg-gavage lower than in controls. At the final stage of testing the animal exceeded the initial body weight, which was measured before starting testing. In the other animals body weight development was normal.
The section of animals showed dark coloured liver, reddened mucous membrane of stomach and punctual bleedings in the stomach. After finalising the testing the animals did not show macroscopic visible abnormalities.
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