Registration Dossier
Registration Dossier
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EC number: 304-802-4 | CAS number: 94279-56-8
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Remarks:
- Type of genotoxicity: other: Assessment
- Type of information:
- other: Expert Assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment as opposed to experimental result
Data source
Reference
- Reference Type:
- other: Expert Assessment
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
- Principles of method if other than guideline:
- Assessment
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- EC Number:
- 304-802-4
- EC Name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- Cas Number:
- 94279-56-8
- Molecular formula:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- IUPAC Name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
Constituent 1
Results and discussion
- Additional information on results:
- Assessment
Any other information on results incl. tables
Assessment
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Assessment
- Executive summary:
According to REACH Annex IX section 8.4, column 2, no further in vivo testing is required if no positive results were obtained in any of the three in vitro studies performed according to REACH Annexes VII and VIII section 8.4. Test data for zirconium acetate (231-492-7) (in vitro) showed no potential for genetic toxicity; in addition, no effects in an in vivo test on silicic acid, sodium salt (215-687-4) were observed; an in vitro study on silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide is planned in order to confirm the absence of potential for genetic toxicity.
The above should be considered as an expert statement to fulfil the REACH registration requirements under Annex IX for endpoint 8.4.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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